Nicotinamide Riboside and Derivatives Alter Intestinal Membrane Function and Gut Microbiome: Preclinical Results

SynopsisResearchers synthesized two new nicotinamide riboside (NR) derivatives—one water-soluble and one oil-soluble—and tested them alongside NR in chick embryos. NR and derivatives altered intest...

Nicotinamide Riboside Restores NAD+ and Improves Heart and Brain Function in Leigh Syndrome: Preclinical Findings

SynopsisMice lacking the mitochondrial complex I subunit Ndufs4 develop Leigh syndrome (LS), marked by serious brain and heart problems. This study found these mice have slow, irregular heartbeats ...

Nicotinamide Riboside Enhances Mitochondrial Protection to Prevent Hearing Loss: Preclinical Findings

Synopsis Damage from oxidative stress is a major cause of hearing loss, particularly through injury to inner hair cell (IHC) synapses, which connect sensory cells to the auditory nerve. This study...

NAD+ Precursors: A Questionable Redundancy: Review

SynopsisIn the last decade, there's been growing interest in treating metabolic and age-related diseases by boosting NAD+ levels in cells. The most common approach is taking NAD+ precursors, a grou...

Nicotinamide Riboside Supports Long-Term Function of Blood Stem Cells: Preclinical Findings

Synopsis Hematopoietic stem cells (HSCs), which produce blood cells, adjust their metabolism depending on whether they are resting or dividing. When HSCs are in maintenance mode, they break down a...

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase NAD+ Levels: Preclinical Findings

SynopsisEukaryotic cells use multiple molecules as NAD+ precursors, but how they work together is unclear. This study identified dihydronicotinic acid riboside (NARH) as a new NAD+ precursor in liv...

Nicotinamide Riboside May Help Reactivate Early Human Embryos in IVF: Preclinical Findings

Synopsis During in vitro fertilization (IVF), nearly 60% of human embryos stop developing early—between the 3- and 8-cell stages—making it a major challenge for successful pregnancies. This study ...

CD38 Inhibitor MK-0159 Preserves NAD+ and Protects the Heart From Ischemia/Reperfusion Injury: Preclinical Findings

Synopsis The enzyme CD38 breaks down important molecules like NAD+ and NADP+, which are vital for cellular energy production and mitochondrial health. When CD38 activity increases—such as during a...

Nicotinamide Riboside Reduces and Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

SynopsisChemotherapy often causes peripheral neuropathy with no effective treatments. This study showed that NR, which activates the NAD-dependent enzyme SIRT2, prevents and reverses nerve damage c...

Nicotinamide Riboside and Caffeine Partially Increase Energy in Alzheimer’s Disease: Preclinical Findings

Synopsis As people age, levels of NAD+, a key molecule for energy production, decline, and low NAD+ is linked to energy problems in late-onset Alzheimer’s disease (LOAD). This study tested whether...

Nicotinamide Riboside and Pterostilbene Therapy Improves Cell Metabolism and Shows Promise in ALS: Preclinical Findings

Synopsis Researchers studying amyotrophic lateral sclerosis (ALS) found that not all patients share the same metabolic profile, meaning their cells process energy differently. In particular, one s...

Early-Life Nicotinamide Riboside Supplementation Protects Against Obesity and Fatty Liver: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a vitamin B3 derivative and NAD+ precursor, is known for its anti-aging and metabolic health benefits, but its long-term effects when given early in life are l...

Nicotinamide Riboside Prevents Nerve Damage From Toxic Chemicals: Preclinical Findings

Synopsis Organophosphate-induced delayed neuropathy (OPIDN) is a serious condition caused by exposure to certain toxic chemicals, leading to nerve degeneration similar to Wallerian degeneration, w...

Autism-Linked Gene NRXN1 Found to Affect Mitochondrial Energy and Metabolism: Preclinical Findings

Synopsis Autism is often linked to differences in language, social interaction, and repetitive behaviors, but it is increasingly recognized that energy metabolism and mitochondrial dysfunction can...

Nicotinamide Riboside Helps Prevent Obesity, Inflammation, and Fibrosis: Preclinical Findings

SynopsisNR supplementation was tested in young and old obese female mice to see if it reduces liver inflammation and fibrosis. In old mice, NR decreased weight gain, fat mass, and improved glucose ...

Nicotinamide Riboside Restores Memory and Protects the Brain After Stroke: Preclinical Findings

Synopsis After a stroke, the brain suffers from a sudden loss of blood flow that damages neurons and causes memory problems. This study found that treating mice with nicotinamide riboside chloride...

Resveratrol and Dimethyl Fumarate Combination Therapy Shows Promise in Friedreich’s Ataxia: Preclinical Findings

Synopsis Friedreich’s ataxia (FA) is a rare inherited disorder that affects the nervous system and heart, with no approved therapies yet. Researchers tested eight compounds—including nicotinamide ...

Nicotinamide Riboside and Natural Antioxidants Protect Against Radiation Damage and Improve Survival: Preclinical Findings

Synopsis Researchers tested whether natural compounds could protect against harmful ionizing radiation, which has applications in medicine, space travel, and biotechnology. In mice exposed to leth...

Nicotinamide Riboside Protects Heart Function and Survival After Circadian Disruption: Preclinical Findings

Synopsis The circadian clock, which regulates daily biological rhythms, also plays an important role in heart health. In this study, mice lacking REV-ERB receptors—key circadian regulators in the ...

NAD+ Precursors Restore Mitochondrial Function and Prevent Nerve Damage in Diabetes: Preclinical Findings

SynopsisDiabetic peripheral neuropathy involves nerve degeneration linked to low NAD+ levels. Researchers tested whether NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside ...