Mitochondrial Targeting Inhibits Breast Cancer Stem Cells: Preclinical Findings

SynopsisMitochondria are vital cell components that generate energy, build essential molecules, and support cell signaling. In cancer, mitochondria often adapt to fuel tumor growth by supplying the...

Nicotinamide Riboside Supports Pancreatic β-Cell Function During Aging and Diet Stress: Preclinical Findings

SynopsisDisturbances in NAD+ metabolism have been linked to many age-related and metabolic diseases like type 2 diabetes. Pancreatic β-cells play a key role in controlling blood sugar, but how NAD+...

Emerging Role of Nicotinamide Riboside in Health and Diseases: Review

SynopsisAmong NAD⁺ precursors, nicotinamide riboside (NR) stands out for its safety, effectiveness, and oral bioavailability. A newly identified form of vitamin B3, NR boosts NAD+ in cells and has ...

Nicotinamide Riboside Restores Exercise Capacity and Mitochondrial Function in Barth Syndrome: Preclinical Findings

SynopsisBarth syndrome, caused by tafazzin mutation, leads to mitochondrial dysfunction and severe exercise intolerance. In a Drosophila model, NR supplementation restored exercise capacity and mit...

Nicotinamide Riboside Restores Gut Microbiota Diversity and Composition in Alzheimer's Disease

SynopsisAlzheimer's disease (AD) is associated with gut microbiota imbalances. In APP/PS1 transgenic AD mice, gut microbiome diversity was reduced and composition altered compared to wild-type mice...

Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF). Journal JACC: Basic to Translational Science Key Outcomes Hig...

Increasing NAD+ Partially Restores Endothelial Cell Function Under Low Oxygen: Preclinical Findings

Synopsis Healthy endothelial cells (ECs)—which line blood vessels—are essential for forming new blood vessels, a process known as angiogenesis. Under low oxygen (hypoxic) conditions, cells activat...

Nicotinamide Riboside and Pterostilbene Do Not Improve Muscle Recovery: Clinical Findings

Objectives To determine whether nicotinamide riboside and pterostilbene (NRPT) supplementation helps activate muscle stem cells and supports muscle repair after a small, controlled injury in elder...

Nicotinamide Riboside Shifts Human Fat Cells Toward Energy-Burning Beige Cells: Preclinical Findings

SynopsisBeige fat cells play key roles in organismal energy and metabolic balance. NR supplementation of human white fat cells derived from stem cells induced mitochondrial biogenesis and expressio...

Nicotinamide Riboside Protects Against Paraquat-Induced Lung Injury: Preclinical Findings

Synopsis Paraquat, a highly toxic herbicide, can cause severe oxidative lung damage and high mortality. This study investigated whether nicotinamide riboside (NR), a vitamin B3 derivative, can pro...

Nicotinamide Riboside Enhances Wound Healing and Reverses Age-Related Declines in Skin Repair: Preclinical Evidence

SynopsisThe skin repairs itself through activation and growth of keratinocyte stem cells, but aging slows this process by unclear mechanisms. This study investigated how the metabolic regulator Pgc...

Nicotinamide Riboside Improves Mitochondrial Function and Exercise Ability in ANT1-Deficiency: Preclinical Findings

SynopsisMitochondrial disorders are often characterized by muscle weakness and fatigue. Mutations in the heart-muscle adenine nucleotide translocator isoform 1 (ANT1) (or ANT1-deficiency) of both h...

Balancing NAD+ Deficits with Nicotinamide Riboside: Therapeutic Possibilities and Limitations: Review

SynopsisLow NAD+ levels have been linked to many health problems related to aging and lifestyle. Supplements with NAD+ precursors (vitamin B3 forms) may help, and nicotinamide riboside (NR) has sho...

Nicotinamide Riboside Injection Increases Muscle Growth in High-Yield Broiler Chickens: Preclinical Findings

SynopsisThis study investigated how injecting nicotinamide riboside (NR) into broiler chicken embryos affects breast muscle development. Injection site mattered: NR injected into the yolk sac incre...

Nicotinamide Riboside and Derivatives Alter Intestinal Membrane Function and Gut Microbiome: Preclinical Results

SynopsisResearchers synthesized two new nicotinamide riboside (NR) derivatives—one water-soluble and one oil-soluble—and tested them alongside NR in chick embryos. NR and derivatives altered intest...

Nicotinamide Riboside Restores NAD+ and Improves Heart and Brain Function in Leigh Syndrome: Preclinical Findings

SynopsisMice lacking the mitochondrial complex I subunit Ndufs4 develop Leigh syndrome (LS), marked by serious brain and heart problems. This study found these mice have slow, irregular heartbeats ...

Nicotinamide Riboside Enhances Mitochondrial Protection to Prevent Hearing Loss: Preclinical Findings

Synopsis Damage from oxidative stress is a major cause of hearing loss, particularly through injury to inner hair cell (IHC) synapses, which connect sensory cells to the auditory nerve. This study...

NAD+ Precursors: A Questionable Redundancy: Review

SynopsisIn the last decade, there's been growing interest in treating metabolic and age-related diseases by boosting NAD+ levels in cells. The most common approach is taking NAD+ precursors, a grou...

Nicotinamide Riboside Supports Long-Term Function of Blood Stem Cells: Preclinical Findings

Synopsis Hematopoietic stem cells (HSCs), which produce blood cells, adjust their metabolism depending on whether they are resting or dividing. When HSCs are in maintenance mode, they break down a...

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase NAD+ Levels: Preclinical Findings

SynopsisEukaryotic cells use multiple molecules as NAD+ precursors, but how they work together is unclear. This study identified dihydronicotinic acid riboside (NARH) as a new NAD+ precursor in liv...