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Emerging Role of Nicotinamide Riboside in Health and Diseases: Review
Synopsis
Among NAD⁺ precursors, nicotinamide riboside (NR) stands out for its safety, effectiveness, and oral bioavailability. A newly identified form of vitamin B3, NR boosts NAD+ in cells and has shown protective effects against neurodegenerative diseases, diabetes, and hearing loss. This review explains NR's role in NAD+ production, methods for synthesizing it chemically or enzymatically, and its impact on normal and diseased physiology, focusing on the most recent research from the past five years.
JOURNAL
Nutrients