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Article: Emerging Role of Nicotinamide Riboside in Health and Diseases: Review

Emerging Role of Nicotinamide Riboside in Health and Diseases: Review


Synopsis

Among NAD⁺ precursors, nicotinamide riboside (NR) stands out for its safety, effectiveness, and oral bioavailability. A newly identified form of vitamin B3, NR boosts NAD+ in cells and has shown protective effects against neurodegenerative diseases, diabetes, and hearing loss. This review explains NR's role in NAD+ production, methods for synthesizing it chemically or enzymatically, and its impact on normal and diseased physiology, focusing on the most recent research from the past five years.

JOURNAL

Nutrients

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Cardiovascular Disease

Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF). Journal JACC: Basic to Translational Science Key Outcomes Hig...

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Ataxia Telangiectasia

Early Nicotinamide Riboside Supplementation Shows Promise in an Individual with Ataxia Telangiectasia: Case Report

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