Article: Nicotinamide Riboside Restores Gut Microbiota Diversity and Composition in Alzheimer's Disease

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Alzheimer's Disease Digestive/Gut Health Preclinical

Nicotinamide Riboside Restores Gut Microbiota Diversity and Composition in Alzheimer's Disease

Synopsis

Alzheimer's disease (AD) is associated with gut microbiota imbalances. In APP/PS1 transgenic AD mice, gut microbiome diversity was reduced and composition altered compared to wild-type mice, with differences between sexes. NR supplementation restored microbiome diversity and normalized bacterial populations, including beneficial genera such as Bifidobacterium and Akkermansia. This suggests NR's therapeutic benefits in AD may involve modulation of gut microbiota and host-microbe interactions.

Journal

Frontiers in Aging Neuroscience

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Cardiovascular Disease

Nicotinamide Riboside Restores Mitochondrial Function and Improves Heart Failure with Preserved Ejection Fraction: Preclinical Findings

SynopsisHeart Failure with Preserved Ejection Fraction (HFpEF) is a serious heart condition without effective treatments. In a mouse model of HFpEF, researchers found impaired mitochondrial fatty a...

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Muscle Health

Nicotinamide Riboside Restores Exercise Capacity and Mitochondrial Function in Barth Syndrome: Preclinical Findings

SynopsisBarth syndrome, caused by tafazzin mutation, leads to mitochondrial dysfunction and severe exercise intolerance. In a Drosophila model, NR supplementation restored exercise capacity and mit...

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