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Nicotinamide Riboside and Derivatives Alter Intestinal Membrane Function and Gut Microbiome: Preclinical Results
Synopsis
Researchers synthesized two new nicotinamide riboside (NR) derivatives—one water-soluble and one oil-soluble—and tested them alongside NR in chick embryos. NR and derivatives altered intestinal gene expression related to nutrient transport and immune function, and modified gut bacterial populations including beneficial Bifidobacterium and Lactobacillus. One derivative increased cecum size. These results suggest NR and its derivatives influence gut health and may modulate microbial communities and intestinal function.
Journal
Nutrients