Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives

To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF).

Journal

JACC: Basic to Translational Science

Key Outcomes

• High-dose NR supplementation was safe and well-tolerated, significantly, and dose-dependently (nearly) doubled whole blood NAD+ levels, and increased peripheral blood mononuclear cell (PBMC) mitochondrial respiration.
• NR also decreased expression of inflammatory markers, such as NLRP3.

Duration

12 weeks

Dose

2000 mg

Study Design

Randomized, double-blind, placebo-controlled study in 30 patients with Stage C heart failure with reduced ejection fraction (HFrEF)