Article: Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase NAD+ Levels: Preclinical Findings

PrevNext
Metabolic Health Preclinical

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase NAD+ Levels: Preclinical Findings

Synopsis

Eukaryotic cells use multiple molecules as NAD+ precursors, but how they work together is unclear. This study identified dihydronicotinic acid riboside (NARH) as a new NAD+ precursor in liver cells. Unlike other precursors, NARH combined with nicotinamide riboside (NR) greatly increased NAD+ levels in cells and mice, due to chemical conversion to dihydronicotinamide riboside (NRH). This is the first report showing NARH acts as a NAD+ precursor and that NAD+ precursors can interact to enhance each other's effects.

Journal

Nutrients

Share

Read more

Neurological Health

Nicotinamide Riboside Reduces and Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

SynopsisChemotherapy often causes peripheral neuropathy with no effective treatments. This study showed that NR, which activates the NAD-dependent enzyme SIRT2, prevents and reverses nerve damage c...

Read more
Cellular Health

NAD+ Precursors: A Questionable Redundancy: Review

SynopsisIn the last decade, there's been growing interest in treating metabolic and age-related diseases by boosting NAD+ levels in cells. The most common approach is taking NAD+ precursors, a grou...

Read more