Article: Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase NAD+ Levels: Preclinical Findings

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Metabolic Health Preclinical

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase NAD+ Levels: Preclinical Findings

Synopsis

Eukaryotic cells use multiple molecules as NAD+ precursors, but how they work together is unclear. This study identified dihydronicotinic acid riboside (NARH) as a new NAD+ precursor in liver cells. Unlike other precursors, NARH combined with nicotinamide riboside (NR) greatly increased NAD+ levels in cells and mice, due to chemical conversion to dihydronicotinamide riboside (NRH). This is the first report showing NARH acts as a NAD+ precursor and that NAD+ precursors can interact to enhance each other's effects.

Journal

Nutrients

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