Article: Nicotinamide Riboside Shifts Human Fat Cells Toward Energy-Burning Beige Cells: Preclinical Findings

PrevNext
Metabolic Health Preclinical

Nicotinamide Riboside Shifts Human Fat Cells Toward Energy-Burning Beige Cells: Preclinical Findings

Synopsis

Beige fat cells play key roles in organismal energy and metabolic balance. NR supplementation of human white fat cells derived from stem cells induced mitochondrial biogenesis and expression of beige fat markers (TBX1, UCP1). NR activated SIRT1 without increasing PARP activity, and increased uncoupled respiration dependent on mitochondrial reactive oxygen species. These effects suggest NR can promote beiging—a process linked to increased energy expenditure—offering a potential strategy against metabolic diseases.

Journal

Frontiers in Cell and Developmental Biology

Share

Read more

Metabolic Health

Nicotinamide Riboside Reverses Metabolic Dysfunction in Werner's Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) features premature aging and metabolic dysfunction, yet mechanisms remain unclear. This study found that loss of the WRN protein accelerates early fat cell formation in...

Read more
COVID/Long-COVID

Nicotinamide Riboside Restores NAD+ Metabolism and Improves Recovery in COVID-19: Preclinical Findings

SynopsisSevere COVID-19 initially causes lung infection and inflammation. Some patients develop Post-Acute Sequelae of COVID (PASC), experiencing ongoing lung problems, fatigue, and cognitive issue...

Read more