Article: Nicotinamide Riboside Shifts Human Fat Cells Toward Energy-Burning Beige Cells: Preclinical Findings

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Metabolic Health Preclinical

Nicotinamide Riboside Shifts Human Fat Cells Toward Energy-Burning Beige Cells: Preclinical Findings

Synopsis

Beige fat cells play key roles in organismal energy and metabolic balance. NR supplementation of human white fat cells derived from stem cells induced mitochondrial biogenesis and expression of beige fat markers (TBX1, UCP1). NR activated SIRT1 without increasing PARP activity, and increased uncoupled respiration dependent on mitochondrial reactive oxygen species. These effects suggest NR can promote beiging—a process linked to increased energy expenditure—offering a potential strategy against metabolic diseases.

Journal

Frontiers in Cell and Developmental Biology

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Preclinical

Nicotinamide Riboside Protects Against Paraquat-Induced Lung Injury: Preclinical Findings

Synopsis Paraquat, a highly toxic herbicide, can cause severe oxidative lung damage and high mortality. This study investigated whether nicotinamide riboside (NR), a vitamin B3 derivative, can pro...

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Clinical

Nicotinamide Riboside and Pterostilbene Do Not Improve Muscle Recovery: Clinical Findings

Objectives To determine whether nicotinamide riboside and pterostilbene (NRPT) supplementation helps activate muscle stem cells and supports muscle repair after a small, controlled injury in elder...

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