Nicotinamide Riboside Reverses Metabolic Dysfunction in Werner's Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) features premature aging and metabolic dysfunction, yet mechanisms remain unclear. This study found that loss of the WRN protein accelerates early fat cell formation in...

Nicotinamide Riboside Boosts NAD+, to Reduce Sleep Need and Support Brain Energy: Preclinical Findings

SynopsisNon-rapid eye movement sleep (NREMS) is linked to lower brain glucose use, which slows metabolic reactions involving NAD+. This study tested whether boosting NAD+ with nicotinamide riboside...

Combination Therapy with Nicotinamide Riboside, Pterostilbene, and Ibudilast Protects Motor Neurons and Prolongs Survival in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by oxidative stress, inflammation, and the progressive death of motor neurons. This study tested a triple t...

NAMPT Inhibition in Neuroendocrine Cancers and the Role of NAD+ Precursors: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme that helps cancer cells make NAD+, a molecule essential for energy production and survival. Drugs that block NAMPT (NAMPT in...

Nicotinamide Riboside Restores Sperm Production and Male Fertility: Preclinical Findings

Synopsis Male infertility is a widespread issue, and one cause may be mutations in the BNC1 gene, which is crucial for sperm development. This study found that mice with a Bnc1 mutation showed spe...

The Impact of Nicotinamide Adenine Dinucleotide Deficiency on Mammalian Development: Review

SynopsisNAD+ is a molecule made from tryptophan or vitamin B3 that's essential for many cell processes. During pregnancy, NAD+ deficiency can cause congenital NAD+ deficiency disorder (CNDD), which...

Impact of NAD+ Metabolism on Ovarian Aging: Review

SynopsisNAD+ is a key coenzyme for energy production and many other vital cell functions, including metabolism, DNA repair, gene regulation, aging, and immune health. Low NAD+ levels are directly l...

Nicotinamide Riboside Attenuates NASH Progression: Preclinical Findings

Synopsis Non-alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease driven by oxidative stress and inflammation. This study investigated whether increasing NADPH, a key molecule ...

High-Dose Nicotinamide Riboside Supplementation Provides Benefits in Parkinson’s Disease: Clinical Findings

Objectives To assess the safety of high-dose NR through the absence of clinically significant adverse events, and assess short-term tolerability and impacts on NAD+, as well as clinical severity o...

Nicotinamide Riboside Improves Mitochondrial Function and Survival Post-Heart Attack: Preclinical Findings

SynopsisMyocardial infarction (MI), or heart attack, is a leading cause of death, and reduced NAD+ levels in the heart can worsen damage after MI. This study tested whether nicotinamide riboside (N...

Nicotinamide Riboside Supplementation in Mild Cognitive Impairment: Clinical Findings

Objectives To determine the safety of oral NR supplementation in older adults with mild cognitive impairment (MCI), and investigate its effects on cognition, brain volume and functioning, and phys...

Role of nadR Gene in Growth and Virulence of Streptococcus suis Bacteria: Preclinical Findings

SynopsisStreptococcus suis serotype 2 (SS2) is a harmful bacterium in pigs that can also infect humans. This study investigated the role of the nadR gene, which helps make and transport NAD+ inside...

Raising NAD+ via Nicotinamide Riboside Enhances Heart Function in Heart Failure: Preclinical Findings

SynopsisBoosting cellular NAD⁺ levels has been shown to prevent heart problems in various models of heart failure, but how it works at the molecular level is not fully understood. Most studies focu...

Maternal Nicotinamide Riboside Protects Against Cardiac Mitochondrial Dysfunction and Supports Fetal Growth: Preclinical Findings

SynopsisGestational hypoxia reduces fetal growth and impairs heart and placental mitochondrial function, partly by limiting NAD+ and energy production. In this study, pregnant guinea pigs were expo...

Nicotinamide Riboside Supplementation in a Child with Mitochondrial Variant and MELAS-Like Symptoms: Case Report

Objectives To assess the potential efficacy of NR supplementation as a therapeutic intervention for a child carrying the mitochondrial DNA variant m.12315G>A, which has previously been identifi...

Nicotinamide Riboside Improves Dental Stem Cell Regeneration: Preclinical Findings

Synopsis Human dental pulp stem cells (hDPSCs) are responsible for repairing and regenerating the inner tooth structure known as the pulp-dentin complex, but their ability to form new dentin is of...

Nicotinamide Riboside and Resveratrol Rejuvenate Stem Cells and Enhance Bone Regeneration in Aging: Preclinical Findings

Synopsis Age-related bone loss is a major cause of disability in older adults, largely due to the aging and dysfunction of bone marrow mesenchymal stem cells (MSCs)—the cells responsible for bone ...

Nicotinamide Riboside Improves Inflammation-Induced Chronic Pain | Preclinical Findings

Synopsis Many patients continue to feel pain even after inflammation has healed, but the reason has been unclear. This study found that mitochondrial dysfunction in sensory neurons—the nerve cells...

Nicotinamide Riboside Ameliorates Joint Damage and Inflammation in Knee Osteoarthritis: Preclinical Findings

Synopsis Knee osteoarthritis (KOA) is a common condition that causes joint pain and stiffness due to cartilage breakdown and inflammation. This study compared the effects of nicotinamide riboside ...

Nicotinamide Riboside Maintains Spermatogonial Stem Cell Function and DNA Integrity: Preclinical Findings

Synopsis Tree shrews, small mammals closely related to primates, are valuable models for biomedical and genetic research. Scientists previously developed a spermatogonial stem cell (SSC) gene-edit...