Nicotinamide Riboside Supplementation Benefits in Werner's Syndrome: Clinical Findings

Objectives To evaluate the safety and efficacy of oral NR supplementation in patients with Werner Syndrome (WS). Journal Aging Cell Key Outcomes NR improved arterial stiffness, as measured by the...

Nicotinamide Riboside Supplementation Enhances Walking Performance in Peripheral Artery Disease: Clinical Findings

Objectives To assess the effects of NR supplementation alone and in combination with resveratrol on the six-minute walk distance in individuals with peripheral artery disease (PAD). Journal Natur...

Nicotinamide Riboside Supplementation Supports Immune Regulation in Human Cells and Blood: Clinical Findings

Objectives To investigate how NR influences the migration of macrophages and the underlying mechanisms behind this effect. Journal Cells Key Outcomes Ex Vivo: NR treatment increased levels of ...

Nicotinamide Riboside Supplementation with Metabolic Activators Improves Cognitive Function in Parkinson’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of NR, L-carnitine tartrate, serine, and N-acetyl-L-cysteine (NAC), could be used to treat Parki...

Nicotinamide Riboside Supplementation Improves Motor Coordination and Eye Movements in Children with Ataxia Telangiectasia: Clinical Findings

Objectives To examine the safety and efficacy of long-term NR supplementation on neuromotor function in patients with ataxia telangiectasia (AT). Journal Movement Disorders Key Outcomes Long-ter...

Nicotinamide Riboside Supplementation and Exercise Are Safe and Feasible in Childhood Cancer Survivors: Clinical Findings

Objectives To evaluate the feasibility and efficacy of a remote telehealth exercise program, with or without NR supplementation, on improving glucose homeostasis and muscle health in adult childho...

Nicotinamide Riboside Supplementation Improves Alzheimer's Biomarkers in Subjective Cognitive Decline and Mild Cognitive Impairment: Clinical Findings

Objectives To test the safety and efficacy of oral NR supplementation on cognition and Alzheimer's disease (AD) blood biomarkers in older adults with subjective cognitive decline and mild cognitiv...

Nicotinamide Riboside Supplementation Reduces Inflammatory Markers in Immune Cells from Healthy Subjects and Psoriasis Patients: Clinical Findings

Objectives To examine how ex-vivo NR supplementation affects adaptive immunity in CD4+ T cells extracted from healthy subjects and those with mild-moderate psoriasis, and to investigate the in viv...

Nicotinamide Riboside Supplementation Increases Brain NAD+ Levels in Humans: Clinical Findings

Objectives To investigate the effects of acute NR supplementation on cerebral NAD+ levels in the healthy human brain using a specialized MRI technique called downfield proton magnetic resonance sp...

Nicotinamide Riboside Supplementation in Mild Cognitive Impairment: Clinical Findings

Objectives To determine the safety of oral NR supplementation in older adults with mild cognitive impariment (MCI), and investigate its effects on cognition, brain volume and functioning, and phys...

Nicotinamide Riboside Supplementation Reduces Oxidative Stress and Enhances Mitochondrial Function in Chronic Kidney Disease Immune Cells: Clinical Findings

Objectives To investigate the effects of NR and CoQ10 on oxidative stress, inflammation, and mitochondrial function in patients with chronic kidney disease (CKD). Journal Clinical Journal of the A...

Nicotinamide Riboside Supplementation May Influence Bacterial Composition: Clinical Findings

Objectives To explore the effects of NR supplementation on the gut microbiota composition in humans. Journal npj Aging Key Outcomes NR supplementation did not affect the diversity or abundance of ...

Nicotinamide Riboside Supplementation Does Not Disrupt Methylation, Including in Individuals with MTHFR Mutations: Clinical Findings

Objectives To investigate the impact of NR supplementation on DNA methylation patterns in the blood cells and muscle tissues of newly diagnosed, dopaminergic treatment-naïve Parkinson's disease (P...

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...

Nicotinamide Riboside Supplementation Increases Muscle Mitochondrial Biogenesis & Gut Health: Clinical Findings

Objectives To investigate the effects of long-term NR supplementation on mitochondrial biogenesis and metabolic health in humans. Journal Science Advances Key Outcomes In the BMI-discordant twi...

Nicotinamide Riboside Supplementation Raises NAD+ and Lowers Alzheimer's-Associated Biomarkers: Clinical Findings

Objectives To evaluate if NR could augment neuronal NAD+ levels and impact markers of neurodegeneration and insulin-signaling in plasma-derived human neuronal extracellular vesicles (NEVs). Journa...

Nicotinamide Riboside Supplementation Is Safe and Well-Tolerated in Heart Failure Patients: Clinical Findings

Objectives To assess the safety and tolerability of NR in patients with Stage C heart failure with reduced ejection fraction (HFrEF). Journal JACC: Basic to Translational Science Key Outcomes Hig...

Nicotinamide Riboside Supplementation Benefits in Early Parkinson's Disease: Clinical Findings

Objectives To assess the safety, tolerability, and cerebral penetration of NR therapy in Parkinson's disease (PD) patients, as well as determine if NR has an impact on their neurometabolic profile...

Nicotinamide Riboside Supplementation Boosts NAD+ and Lowers Inflammatory Immune Signaling in Lupus: Clinical Findings

Objectives To explore the anti-inflammatory effects of NR in monocytes (a type of white blood cell; immune cell) extracted from young, healthy subjects following supplementation. Additionally, the...

Nicotinamide Riboside Supplementation with Metabolic Cofactors Reduces Liver Fat in NAFLD Patients: Clinical Findings

Objectives To determine if combined metabolic activator supplementation (CMA) will reduce hepatic fat in nonalcoholic fatty liver disease (NAFLD) patients. Journal Molecular Systems Biology Key O...