Nicotinamide Riboside and Resveratrol Rejuvenate Stem Cells and Enhance Bone Regeneration in Aging: Preclinical Findings

Synopsis

Age-related bone loss is a major cause of disability in older adults, largely due to the aging and dysfunction of bone marrow mesenchymal stem cells (MSCs)—the cells responsible for bone repair and regeneration. This study developed a novel nanoplatform that specifically targets senescent MSCs to restore their function and promote bone healing. Researchers identified a new senescent MSC surface marker, Kremen1, and designed nanoparticles carrying nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, and resveratrol (RSV), a SIRT1 activator. The nanoparticles were coated with anti-Kremen1 antibodies, allowing them to selectively bind to aging MSCs. Once inside the cells, they released NR and RSV in response to senescence-associated enzyme activity, boosting NAD+ levels, activating the SIRT1 pathway, and delaying cellular aging. In both cell and animal models, this therapy significantly enhanced bone formation and regeneration. This pioneering approach demonstrates a promising anti-aging strategy for treating osteoporosis and other age-related bone disorders by rejuvenating aged stem cells through targeted NAD+ and SIRT1 activation.

Journal

Small