Article: Nicotinamide Riboside Supplementation in Mild Cognitive Impairment: Clinical Findings

Nov 23, 2023 Clinical Mild Cognitive Impairment Neurological Health

Nicotinamide Riboside Supplementation in Mild Cognitive Impairment: Clinical Findings

Objectives

To determine the safety of oral NR supplementation in older adults with mild cognitive impairment (MCI), and investigate its effects on cognition, brain volume and functioning, and physical function.

Journal

GeroScience

Key Outcomes

Cognitive function measures remained stable in both NR and placebo groups throughout the study.
Global methylation analyses trended towards a modest NR-associated increase in DNA methylation.

Duration

10 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, phase II, pilot study in 20 primarily Hispanic older adults with mild cognitive impairment (MCI)

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