%20are%20responsible%20for%20repairing%20and%20regenerating%20the%20inner%20tooth%20structure%20known%20as%20the%20pulp-dentin%20complex,%20but%20their%20ability%20to%20form%20new%20dentin%20is%20of...){kind=link}
Nicotinamide Riboside Improves Dental Stem Cell Regeneration: Preclinical Findings
Synopsis
Human dental pulp stem cells (hDPSCs) are responsible for repairing and regenerating the inner tooth structure known as the pulp-dentin complex, but their ability to form new dentin is often limited. This study found that nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, enhances the viability, energy levels, and regenerative potential of hDPSCs. Pretreating these stem cells with NR reduced cellular aging, improved their ability to differentiate into odontoblast-like cells, and increased the formation of dentin-like tissue when transplanted into mice. Further analysis showed that NR works by inhibiting the HIF-1 signaling pathway, reducing HIF-1α expression, which helps guide cells toward tissue repair instead of stress responses. These results suggest that NR could be used to enhance stem cell-based dental therapies, improving outcomes in tooth repair and pulp regeneration.
Journal
Stem Cells