Nicotinamide Riboside Supplementation Reduces Inflammatory Markers in Immune Cells from Healthy Subjects and Psoriasis Patients: Clinical Findings

Objectives To examine how ex-vivo NR supplementation affects adaptive immunity in CD4+ T cells extracted from healthy subjects and those with mild-moderate psoriasis, and to investigate the in viv...

Nicotinamide Riboside Partially Restores Cellular Energy in Mitochondrial Disease: Preclinical Findings

Synopsis Mitochondrial diseases arise from genetic mutations that impair energy production in cells. One of the most common, the m.3243A>G mutation, disrupts complex I of the mitochondrial resp...

Nicotinamide Riboside Enhances Restores Stem Cell Function in Aging Adipose Tissue: Preclinical Findings

Synopsis As people age, body fat redistributes, with less fat stored under the skin and more accumulating around internal organs—a shift linked to insulin resistance and metabolic decline. This pr...

Nicotinamide Riboside Reduces T Cell Exhaustion and Improves Survival in Sepsis: Preclinical Findings

Synopsis Sepsis, a life-threatening response to infection, often causes the immune system to weaken through T cell exhaustion, leading to poor recovery and high mortality. This study found that in...

Nicotinamide Riboside Protects Against Neurotoxicity in Zebrafish: Preclinical Findings

Synopsis Decabromodiphenyl ethane (DBDPE) is a new flame retardant that is increasingly found in the environment and living organisms. Its harmful effects on biology are known, but the exact mecha...

Nicotinamide Riboside Protects Spinal Cord Tissue and Recovery After Injury: Preclinical Findings

Synopsis After a spinal cord injury (SCI), tissue damage continues to spread beyond the original site, worsening nerve loss and impairing movement. One major factor driving this damage is the rapi...

Nicotinamide Riboside Protects Against Diabetic Kidney Disease: Preclinical Findings

SynopsisDiabetic kidney disease (DKD) is a leading cause of kidney failure, linked to inflammation and mitochondrial dysfunction. This study evaluated whether boosting NAD+ metabolism via nicotinam...

Nicotinamide Riboside Prevents Age-Related Hearing Loss: Preclinical Findings

SynopsisAge‐related hearing loss (ARHL) is the most common sensory disability associated with human aging. Yet, there are no approved measures for preventing or treating this debilitating condition...

Nicotinamide Riboside Restores NAD+ Metabolism and Improves Recovery in COVID-19: Preclinical Findings

SynopsisSevere COVID-19 initially causes lung infection and inflammation. Some patients develop Post-Acute Sequelae of COVID (PASC), experiencing ongoing lung problems, fatigue, and cognitive issue...

Restoring NAD+ with Nicotinamide Riboside Improves Metabolism and Autophagy in DNA Repair Deficiency: Preclinical Findings

SynopsisLoss of Rev1, a DNA repair protein, causes replication stress, mitochondrial dysfunction, and metabolic imbalance. This study found that mouse embryonic fibroblasts lacking Rev1 had altered...

Nicotinamide Riboside Protects Against Ovarian Aging: Preclinical Findings

Synopsis Recent research shows that NAD+, an important molecule for cell health, plays a key role in ovarian aging, but it was unclear how NAD+ made from scratch in the body affects fertility. In ...

Nicotinamide Riboside Supports Cartilage Cell Survival and Normal Bone Growth: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is critical for energy metabolism and bone development. Researchers generated mice lacking NAMPT, an essential enzyme in the NAD+ salvage pathway,...

Nicotinamide Riboside Improves Insulin Resistance by Boosting Mitochondrial Function in Skeletal Muscle: Preclinical Findings

SynopsisHigh-fat diet-induced insulin resistance (IR) in skeletal muscle is linked to mitochondrial dysfunction and oxidative stress. This study assessed whether nicotinamide riboside (NR) could re...

Nicotinamide Riboside Enhances SIRT5 Activity to Support Mitochondrial Function: Preclinical Findings

Synopsis Sirtuins are a family of enzymes that depend on NAD+ to regulate key cellular processes such as DNA repair, metabolism, and aging. Among them, SIRT5 plays an important role in protecting ...

Acute Effects of Combined Metabolic Activators and NAD+ Precursors on NAD+ Metabolites: Clinical Findings

Objectives To investigate the safety and acute effects of six different combined metabolic activators (CMA) formulations, each containing 1000 mg of one of the following NAD+ precursors: nicotinam...

Nicotinamide Riboside Protects Against Ovarian Injury in Sepsis: Preclinical Findings

Synopsis This study examined whether nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, can protect against oxidative stress and tissue injury caused by sepsis in rats. Researchers cre...

Impact of Nicotinamide Riboside and β-Hydroxybutyrate on Lifespan: Preclinical Findings

Synopsis Researchers studying the longevity of C. elegans (a model organism for aging research) found that nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—and beta-hydroxybutyrate (BH...

Impact of Nicotinamide Riboside on DNA Repair: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for enzymes like sirtuins and PARPs, which help cells repair DNA double-strand breaks (DSBs)—a severe type of genetic damage caused by ra...

Nicotinamide Riboside Restores NAD+ and Improves Survival of Neurons with Autophagy Defects: Preclinical Findings

SynopsisAutophagy is a cellular recycling process vital for neuron survival, and its failure contributes to neurodegenerative diseases. This study generated human neurons lacking the autophagy gene...

Nicotinamide Riboside Protects Against Fat-Induced Liver Damage: Preclinical Findings

Synopsis This study explored how palmitate, a common saturated fat found in the bloodstream, contributes to fatty liver disease by altering cell metabolism. Researchers found that palmitate activa...