Nicotinamide Riboside Supplementation Improves Motor Coordination and Eye Movements in Children with Ataxia Telangiectasia: Clinical Findings

Objectives To examine the safety and efficacy of long-term NR supplementation on neuromotor function in patients with ataxia telangiectasia (AT). Journal Movement Disorders Key Outcomes Long-ter...

Roles of NAD+ in Health and Aging: Review

SynopsisNAD+ supports essential processes including metabolism, energy production, DNA repair, mitophagy, inflammation control, and brain function, but its levels drop with aging, affecting all rec...

Nicotinamide Riboside and Phycocyanin Oligopeptides Reduce Stress-Induced Cellular Aging: Preclinical Findings

Synopsis Chronic stress accelerates cellular aging and increases inflammation and oxidative damage, but certain nutrients may help protect against these effects. In this study, researchers tested ...

Nicotinamide Riboside Defends Against Sulfur Mustard-Related Toxicity: Preclinical Findings

Synopsis Sulfur mustard (SM) and related chemicals are toxic compounds that damage DNA by depleting NAD+, a molecule essential for DNA repair and energy balance. This study examined whether restor...

Effects of Nicotinamide Riboside on Bacterial Respiratory Epithelial Infections: Preclinical Findings

Synopsis This study found that during infection, lung cells experience a breakdown in the NAD+ salvage pathway, which reduces NAD+ production—a molecule crucial for energy metabolism and immune de...

Genetic Background Influences Nicotinamide Riboside Response in Barth Syndrome: Preclinical Findings

SynopsisBarth Syndrome is a rare genetic disorder caused by mutations in the TAFAZZIN (TAZ) gene, which affects mitochondrial function by disrupting cardiolipin remodeling. While clinical trials ar...

Effects of Increasing NAD+ on the Pluripotency of Stem Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for cellular energy and signaling, and recent studies suggest it may influence how embryonic stem cells maintain their ability to become ...

Effect of the Mediterranean Diet Supplemented with Nicotinamide Riboside, Pterostilbene, and/or Coconut Oil in ALS Patients: Pilot Clinical Findings

Objectives To assess the effects of a Mediterranean diet supplemented with nicotinamide riboside (NR) and pterostilbene, with or without coconut oil, on body weight, composition, BMI, and overall ...

Nicotinamide Riboside Restores Intestinal Health and Mitochondrial Function in Colitis: Preclinical Findings

SynopsisReduced levels of PGC1α, a key regulator of cellular energy, contribute to inflammatory bowel disease (IBD). In both mice with experimental colitis and humans with ulcerative colitis, NAD+ ...

Clinical Outcomes of SAMe and Nicotinamide Riboside Supplementation in a Child with Arts Syndrome: Case Report

Objectives To examine the effects of supplementation of S-adenosylmethionine (SAMe) and NR in a child with Arts syndrome and compare to previous Arts syndrome patients who received SAMe with or wi...

Nicotinamide Riboside Protects Against Ionizing Radiation-Induced Aging: Preclinical Findings

Synopsis Radiation therapy effectively kills cancer cells but can also damage healthy tissues, leading to premature aging and long-term side effects in survivors. In this study, researchers used a...

Nicotinamide Riboside and Nicotinamide Mononucleotide Prevent Oxidative Stress in Blood Vessel Cells From COVID-19 Patients: Preclinical Findings

SynopsisCOVID-19 is associated with vascular endothelial dysfunction, but mechanisms remain unclear. This study exposed human aortic endothelial cells (HAECs) to plasma from hospitalized COVID-19 p...

Nicotinamide Riboside Protects Retinal Nerve Cells in Glaucoma: Preclinical Findings

SynopsisGlaucoma causes progressive retinal ganglion cell (RGC) degeneration and vision loss, often associated with elevated intraocular pressure (IOP). This study tested whether oral administratio...

Using Engineered Cancer Cells to Identify How Orphan Cytotoxins Work: Preclinical Findings

Synopsis Orphan cytotoxins are small molecules whose exact targets or mechanisms are unknown. Understanding how they work can reveal new research tools and potential therapies. To help identify th...

Nicotinamide Riboside Supplementation Reduces Inflammatory Markers in Immune Cells from Healthy Subjects and Psoriasis Patients: Clinical Findings

Objectives To examine how ex-vivo NR supplementation affects adaptive immunity in CD4+ T cells extracted from healthy subjects and those with mild-moderate psoriasis, and to investigate the in viv...

Nicotinamide Riboside Partially Restores Cellular Energy in Mitochondrial Disease: Preclinical Findings

Synopsis Mitochondrial diseases arise from genetic mutations that impair energy production in cells. One of the most common, the m.3243A>G mutation, disrupts complex I of the mitochondrial resp...

Nicotinamide Riboside Enhances Restores Stem Cell Function in Aging Adipose Tissue: Preclinical Findings

Synopsis As people age, body fat redistributes, with less fat stored under the skin and more accumulating around internal organs—a shift linked to insulin resistance and metabolic decline. This pr...

Nicotinamide Riboside Reduces T Cell Exhaustion and Improves Survival in Sepsis: Preclinical Findings

Synopsis Sepsis, a life-threatening response to infection, often causes the immune system to weaken through T cell exhaustion, leading to poor recovery and high mortality. This study found that in...

Nicotinamide Riboside Protects Against Neurotoxicity in Zebrafish: Preclinical Findings

Synopsis Decabromodiphenyl ethane (DBDPE) is a new flame retardant that is increasingly found in the environment and living organisms. Its harmful effects on biology are known, but the exact mecha...

Nicotinamide Riboside Protects Spinal Cord Tissue and Recovery After Injury: Preclinical Findings

Synopsis After a spinal cord injury (SCI), tissue damage continues to spread beyond the original site, worsening nerve loss and impairing movement. One major factor driving this damage is the rapi...