The Impact of Nicotinamide Adenine Dinucleotide Deficiency on Mammalian Development: Review

Synopsis

NAD+ is a molecule made from tryptophan or vitamin B3 that's essential for many cell processes. During pregnancy, NAD+ deficiency can cause congenital NAD+ deficiency disorder (CNDD), which may result in birth defects or miscarriage. Mouse studies mimicking human genetic mutations have shown that CNDD can be prevented with dietary supplements. Some causes include gene defects in NAD+ production or low availability of NAD precursors from diet or absorption. While NAD+ deficiency is a known cause of poor pregnancy outcomes, its prevalence is unknown, and more research is needed to understand how it disrupts embryo development and how to prevent it.

JOURNAL

Antioxidants & Redox Signaling