NAD+ Depletion Drives Cartilage Damage in Osteoarthritis: Preclinical Findings

Synopsis Earlier research showed that people with osteoarthritis (OA) have lower levels of NAD+, an important energy-related molecule, in their cartilage. This study found that NAD+ levels are red...

Nicotinamide Riboside Ameliorates Joint Damage and Inflammation in Knee Osteoarthritis: Preclinical Findings

Synopsis Knee osteoarthritis (KOA) is a common condition that causes joint pain and stiffness due to cartilage breakdown and inflammation. This study compared the effects of nicotinamide riboside ...

Nicotinamide Riboside Ameliorates Inflammation and Joint Damage in Rheumatoid Arthritis: Preclinical Findings

Synopsis This study investigated how NAD+ metabolism affects rheumatoid arthritis (RA) and whether NAD+ boosters could improve disease outcomes. Researchers analyzed blood samples from 253 partici...

Nicotinamide Riboside Activates Mitochondrial Stress Response to Protect Against Osteoarthritis: Preclinical Findings

Synopsis The mitochondrial unfolded protein response (UPRmt) is a protective system that helps mitochondria—the cell’s energy centers—function properly when damaged or stressed. Healthy mitochondr...