Impact of NAD+ Metabolism on Ovarian Aging: Review

Synopsis

NAD+ is a key coenzyme for energy production and many other vital cell functions, including metabolism, DNA repair, gene regulation, aging, and immune health. Low NAD+ levels are directly linked to age-related diseases, and boosting NAD+ in animal studies has improved health outcomes. In ovarian aging—a natural decline in egg number and quality leading to menopause—NAD+ levels drop over time, but NAD+ precursors may improve egg quality and slow ovarian aging. This review examines factors that influence ovarian aging, the features of NAD+ precursors, and the latest research on NAD+ supplementation in improving fertility for women of advanced maternal age.

JOURNAL

Immunity & Ageing

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Clinical

High-Dose Nicotinamide Riboside Supplementation Provides Benefits in Parkinson’s Disease: Clinical Findings

Objectives To assess the safety of high-dose NR through the absence of clinically significant adverse events, and assess short-term tolerability and impacts on NAD+, as well as clinical severity o...

Reproductive Health

The Impact of Nicotinamide Adenine Dinucleotide Deficiency on Mammalian Development: Review

SynopsisNAD+ is a molecule made from tryptophan or vitamin B3 that's essential for many cell processes. During pregnancy, NAD+ deficiency can cause congenital NAD+ deficiency disorder (CNDD), which...

Impact of NAD+ Metabolism on Ovarian Aging: Review

Synopsis

JOURNAL

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