Nicotinamide Riboside Hydrogel Enhances T Cell Therapy: Preclinical Findings

Synopsis T cell-based immunotherapy (TCBI) is a promising cancer treatment, but its success is often limited by weak immune activation, T cell exhaustion, and tumor immune evasion through the PD-1...

Nicotinamide Riboside and CoQ10 Supplementation May Support Kidney Health in Chronic Kidney Disease: Clinical Findings

Objectives To examine the effects of NR and coenzyme Q10 (CoQ10) supplementation alone for six weeks on physical endurance, work efficiency, and metabolic profile in chronic kidney disease (CKD) p...

Nicotinamide Riboside Improves Social Preference Deficits: Preclinical Findings

SynopsisNAD-derived molecules regulate oxytocin release, which influences social behaviors. This study tested the effects of nicotinamide riboside (NR) supplementation on social interaction in mice...

Effects of Nicotinamide Riboside in Hyperammonemia: Preclinical Findings

Synopsis Excess ammonia in the body disrupts metabolism and contributes to cellular aging (senescence) by damaging mitochondria and disturbing the NAD+/NADH redox balance, which is vital for energ...

Nicotinamide Riboside Ameliorates Inflammation and Joint Damage in Rheumatoid Arthritis: Preclinical Findings

Synopsis This study investigated how NAD+ metabolism affects rheumatoid arthritis (RA) and whether NAD+ boosters could improve disease outcomes. Researchers analyzed blood samples from 253 partici...

Interferon-β in Combination with Nicotinamide Riboside Offers Protection Against Sepsis: Preclinical Findings

Synopsis Sepsis is a severe, often fatal condition in which the body’s immune response to infection causes widespread inflammation and organ failure. This study found that combining interferon-β (...

Nicotinamide Riboside Supplementation May Influence Bacterial Composition: Clinical Findings

Objectives To explore the effects of NR supplementation on the gut microbiota composition in humans. Journal npj Aging Key Outcomes NR supplementation did not affect the diversity or abundance of...

Metabolic Engineering of E. coli Enables Efficient Biosynthesis of Nicotinamide Riboside: Preclinical Findings

Synopsis Researchers developed a highly efficient biotechnological method to produce nicotinamide riboside (NR)—a vital precursor of NAD+—using engineered E. coli bacteria. They identified that th...

Nicotinamide Riboside Slows Liver Cancer Growth and Metastasis: Preclinical Findings

SynopsisNicotinamide adenine dinucleotide (NAD+) metabolism has emerged as a target in cancer treatment. This study evaluated the effects of nicotinamide riboside (NR), a NAD+ precursor, on hepatoc...

Nicotinamide Riboside Supplementation Does Not Disrupt Methylation, Including in Individuals with MTHFR Mutations: Clinical Findings

Objectives To investigate the impact of NR supplementation on DNA methylation patterns in the blood cells and muscle tissues of newly diagnosed, dopaminergic treatment-naïve Parkinson's disease (P...

Nicotinamide Riboside Protects Gut Nerve Health and Improves Gastrointestinal Transit in Diabetes: Preclinical Findings

SynopsisDiabetes causes systemic oxidative stress that often leads to nerve damage in the enteric nervous system, impairing gut motility and causing symptoms such as constipation or diarrhea. Using...

Nicotinamide Riboside and Nicotinamide Mononucleotide Protect Against Kidney Injury: Preclinical Findings

Synopsis This study uncovered how NAD+ deficiency contributes to kidney disease by damaging mitochondria and triggering inflammation. Through metabolic analysis of human kidney samples, researcher...

Nicotinamide Riboside Corrects Metabolic Imbalances and Mitochondrial Dysfunction in Citrin Deficiency: Preclinical Findings

SynopsisCitrin deficiency (CD) is a genetic metabolic disorder caused by loss of the mitochondrial transporter CITRIN, which plays a role in the urea cycle and malate–aspartate shuttle. Patients wi...

Nicotinamide Riboside Supplementation Improves Fetal Growth Under Hypoglycemia: Preclinical Findings

Synopsis Nicotinamide riboside (NR), a form of vitamin B3 known for its metabolic benefits, may play an important role in glucose control during pregnancy. This study examined how NR affects blood...

Nicotinamide Riboside and Calorie Restriction Improve Gut Microbiota and Reduce Liver Fat and Inflammation: Preclinical Findings

SynopsisMetabolic dysfunction–related fatty liver disease currently has no specific therapy. This study tested nicotinamide riboside (NR) and dietary restriction (DR) in rats with diet-induced obes...

Nicotinamide Riboside Supplementation Partially Restores Sense of Smell in Aging: Preclinical Findings

SynopsisLoss of smell is an early and common feature of both aging and neurodegenerative diseases such as Alzheimer's and Parkinson's. This study investigated behavioral and molecular changes in th...

Nicotinamide Riboside Boosts NAD+ to Improve Telomere Stability: Preclinical Findings

SynopsisTelomere biology disorders (TBDs), such as dyskeratosis congenita (DC), are characterized by critically short telomeres and often lead to bone marrow failure. A key metabolic molecule, NAD+...

Timing of NAD+ Precursors Determines Neuroprotection After Stroke: Preclinical Findings

Synopsis Researchers studying nicotinamide riboside (NR) and nicotinamide (NAM)—both vitamin B3-based NAD+ boosters—found that the timing of supplementation plays a critical role in brain recovery...

Beyond Pellagra—NAD+ Deficiency in Aging and Disease: Review

SynopsisInterest in NAD+ has surged because low NAD+ levels are linked to many health problems, including metabolic diseases, neurodegeneration, reproductive disorders, cancer, and aging. Researche...

Nicotinamide Riboside Supplementation Combined with Metabolic Activators Improves Cognitive Function in Alzheimer’s Disease: Clinical Findings

Objectives To investigate whether supplementation of combined metabolic activators (CMA) consisting of L-carnitine tartrate, nicotinamide riboside (NR), serine, and N-acetyl-L-cysteine (NAC), coul...