Nicotinamide Riboside Protects Against Diabetic Kidney Disease: Preclinical Findings

SynopsisDiabetic kidney disease (DKD) is a leading cause of kidney failure, linked to inflammation and mitochondrial dysfunction. This study evaluated whether boosting NAD+ metabolism via nicotinam...

Nicotinamide Riboside Prevents Age-Related Hearing Loss: Preclinical Findings

SynopsisAge‐related hearing loss (ARHL) is the most common sensory disability associated with human aging. Yet, there are no approved measures for preventing or treating this debilitating condition...

Nicotinamide Riboside Restores NAD+ Metabolism and Improves Recovery in COVID-19: Preclinical Findings

SynopsisSevere COVID-19 initially causes lung infection and inflammation. Some patients develop Post-Acute Sequelae of COVID (PASC), experiencing ongoing lung problems, fatigue, and cognitive issue...

Restoring NAD+ with Nicotinamide Riboside Improves Metabolism and Autophagy in DNA Repair Deficiency: Preclinical Findings

SynopsisLoss of Rev1, a DNA repair protein, causes replication stress, mitochondrial dysfunction, and metabolic imbalance. This study found that mouse embryonic fibroblasts lacking Rev1 had altered...

Nicotinamide Riboside Protects Against Ovarian Aging: Preclinical Findings

Synopsis Recent research shows that NAD+, an important molecule for cell health, plays a key role in ovarian aging, but it was unclear how NAD+ made from scratch in the body affects fertility. In ...

Nicotinamide Riboside Supports Cartilage Cell Survival and Normal Bone Growth: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is critical for energy metabolism and bone development. Researchers generated mice lacking NAMPT, an essential enzyme in the NAD+ salvage pathway,...

Nicotinamide Riboside Improves Insulin Resistance by Boosting Mitochondrial Function in Skeletal Muscle: Preclinical Findings

SynopsisHigh-fat diet-induced insulin resistance (IR) in skeletal muscle is linked to mitochondrial dysfunction and oxidative stress. This study assessed whether nicotinamide riboside (NR) could re...

Nicotinamide Riboside Enhances SIRT5 Activity to Support Mitochondrial Function: Preclinical Findings

Synopsis Sirtuins are a family of enzymes that depend on NAD+ to regulate key cellular processes such as DNA repair, metabolism, and aging. Among them, SIRT5 plays an important role in protecting ...

Acute Effects of Combined Metabolic Activators and NAD+ Precursors on NAD+ Metabolites: Clinical Findings

Objectives To investigate the safety and acute effects of six different combined metabolic activators (CMA) formulations, each containing 1000 mg of one of the following NAD+ precursors: nicotinam...

Nicotinamide Riboside Protects Against Ovarian Injury in Sepsis: Preclinical Findings

Synopsis This study examined whether nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, can protect against oxidative stress and tissue injury caused by sepsis in rats. Researchers cre...

Impact of Nicotinamide Riboside and β-Hydroxybutyrate on Lifespan: Preclinical Findings

Synopsis Researchers studying the longevity of C. elegans (a model organism for aging research) found that nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—and beta-hydroxybutyrate (BH...

Impact of Nicotinamide Riboside on DNA Repair: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for enzymes like sirtuins and PARPs, which help cells repair DNA double-strand breaks (DSBs)—a severe type of genetic damage caused by ra...

Nicotinamide Riboside Restores NAD+ and Improves Survival of Neurons with Autophagy Defects: Preclinical Findings

SynopsisAutophagy is a cellular recycling process vital for neuron survival, and its failure contributes to neurodegenerative diseases. This study generated human neurons lacking the autophagy gene...

Nicotinamide Riboside Protects Against Fat-Induced Liver Damage: Preclinical Findings

Synopsis This study explored how palmitate, a common saturated fat found in the bloodstream, contributes to fatty liver disease by altering cell metabolism. Researchers found that palmitate activa...

Nicotinamide Riboside Hydrogel Enhances T Cell Therapy: Preclinical Findings

Synopsis T cell-based immunotherapy (TCBI) is a promising cancer treatment, but its success is often limited by weak immune activation, T cell exhaustion, and tumor immune evasion through the PD-1...

Nicotinamide Riboside and CoQ10 Supplementation May Support Kidney Health in Chronic Kidney Disease: Clinical Findings

Objectives To examine the effects of NR and coenzyme Q10 (CoQ10) supplementation alone for six weeks on physical endurance, work efficiency, and metabolic profile in chronic kidney disease (CKD) p...

Nicotinamide Riboside Improves Social Preference Deficits: Preclinical Findings

SynopsisNAD-derived molecules regulate oxytocin release, which influences social behaviors. This study tested the effects of nicotinamide riboside (NR) supplementation on social interaction in mice...

Effects of Nicotinamide Riboside in Hyperammonemia: Preclinical Findings

Synopsis Excess ammonia in the body disrupts metabolism and contributes to cellular aging (senescence) by damaging mitochondria and disturbing the NAD+/NADH redox balance, which is vital for energ...

Nicotinamide Riboside Ameliorates Inflammation and Joint Damage in Rheumatoid Arthritis: Preclinical Findings

Synopsis This study investigated how NAD+ metabolism affects rheumatoid arthritis (RA) and whether NAD+ boosters could improve disease outcomes. Researchers analyzed blood samples from 253 partici...

Interferon-β in Combination with Nicotinamide Riboside Offers Protection Against Sepsis: Preclinical Findings

Synopsis Sepsis is a severe, often fatal condition in which the body’s immune response to infection causes widespread inflammation and organ failure. This study found that combining interferon-β (...