Article: Nicotinamide Riboside Preserves Oocyte Quality and Prevents Postovulatory Aging: Preclinical Findings

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Preclinical Reproductive Health

Nicotinamide Riboside Preserves Oocyte Quality and Prevents Postovulatory Aging: Preclinical Findings

Synopsis

After ovulation, oocytes (eggs) begin to age, leading to lower fertilization success and embryo quality during assisted reproductive technologies (ART) such as IVF. This process, known as postovulatory aging (POA), causes oxidative stress, mitochondrial dysfunction, and chromosomal damage in eggs. In this study, researchers found that supplementing cultured mouse oocytes with nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—protected eggs from aging-related damage. NR treatment increased NAD+ levels, reduced reactive oxygen species (ROS), restored mitochondrial function, and normalized spindle assembly and chromosome alignment. It also decreased markers of DNA damage (γH2AX) and improved embryonic development potential after fertilization. These effects were mediated through the NAD+/SIRT1 antioxidant pathway. The findings suggest that NR is a safe and effective compound that can delay egg aging, enhance oocyte quality, and increase the success rate of fertility treatments.

Journal

Journal of Assisted Reproduction and Genetics

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Cancer

Nicotinamide Riboside Protects CD8+ T Cells From Exhaustion by Improving Mitochondrial Health: Preclinical Findings

SynopsisProtecting mitochondria in CD8+ T cells is important for improving cancer immunotherapy. This study tested whether nicotinamide riboside (NR) could prevent T cell exhaustion. In lab models,...

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Cellular Health

Nicotinamide Riboside Inhibits CD38 in Living Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for energy production, metabolism, and cell signaling, but its levels naturally decline with age and disease. One key reason for this...

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