Article: Nicotinamide Riboside Reduces Airway Inflammation in COPD: Clinical Findings

Nov 15, 2024 Clinical Healthy Aging & Longevity Respiratory Health

Nicotinamide Riboside Reduces Airway Inflammation in COPD: Clinical Findings

Objectives

To investigate the effects of NR supplementation on airway inflammation and cellular senescence in previously smoking patients with chronic obstructive pulmonary disease (COPD).

Journal

Nature Aging

Key Outcomes

NR increased blood NAD+ levels in COPD patients, with a 44% greater rise compared to lung-healthy controls.
NR supplementation reduced airway inflammation, evidenced by a marked decrease in an inflammatory marker, interleukin-8 (IL-8) in the sputum, with the effect lasting for 12 weeks post-treatment.
In COPD patients, NR appeared to enhance gene pathways that support DNA integrity in the airways and potentially slow down cellular aging by reducing cellular senescence.

Duration

6 weeks

Dose

2000 mg

Study Design

Randomized, double-blind, placebo-controlled study in 40 COPD patients

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