Article: Nicotinamide Riboside and Resveratrol Enhance Wound Healing in Diabetic Rats: Preclinical Findings

PrevNext
Diabetes Preclinical Skin Health

Nicotinamide Riboside and Resveratrol Enhance Wound Healing in Diabetic Rats: Preclinical Findings

Synopsis

Diabetes impairs wound healing by disrupting autophagy and promoting apoptosis. In a type 1 diabetic rat model, systemic and topical nicotinamide riboside (NR) and resveratrol (RSV) significantly improved wound closure. Treatment boosted SIRT1, FOXO1, VEGF, LC3IIβ, ATG5, and Bcl-2 expression, while reducing pro-apoptotic markers BAX and Caspase-3. These changes restored balanced autophagy, reduced apoptosis, and enhanced vascularization. Stereological analysis confirmed improved epidermal/dermal structure, collagen density, fibroblast proliferation, and vascularity. The combined NR+RSV treatment produced the strongest effects. Overall, NR and RSV enhance diabetic wound healing by activating the SIRT1–FOXO1 axis and correcting autophagy–apoptosis imbalance, supporting their potential as targeted therapies for diabetic wounds.

Journal

The Journal of Nutritional Biochemistry

Share

Read more

Liver Health

Nicotinamide Riboside Improves Fructose-Induced Lipid Metabolism Disorders: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, protects against fat metabolism disorders caused by high fructose intake. Mice given a 20% fructose ...

Read more
Pharmacokinetic/Safety

Nicotinamide Riboside: Review

SynopsisNicotinamide riboside (NR) is a well-studied NAD+ precursor with multiple health benefits linked to increasing NAD+ levels in the body. Studies in animals and humans show NR may help treat ...

Read more