NAD+ Depletion Is Central to Placental Dysfunction in an Inflammatory Subclass of Preeclampsia: Preclinical Findings

Synopsis

Preeclampsia (PE) is a dangerous pregnancy complication marked by high blood pressure, inflammation, and placental dysfunction, leading to serious risks for both mother and baby. This study identified a specific inflammation-driven form of PE where the placenta shows depleted NAD+ levels, increased NAD+-consuming enzyme activity, mitochondrial damage, and oxidative stress. Using human placental cells, researchers found that inflammation impairs mitochondrial energy production and cell function, but these effects were reversed by nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster. In a rat model of inflammation-induced PE, NR supplementation throughout pregnancy prevented maternal hypertension, improved fetal and placental growth, and reduced oxidative and inflammatory damage. The results show that maintaining healthy NAD+ and mitochondrial function is vital for placental health and that NR may serve as a promising, safe therapy to prevent preeclampsia.

Journal

Life Science Alliance