Article: Nicotinamide Riboside Supplementation and Exercise Are Safe and Feasible in Childhood Cancer Survivors: Clinical Findings

Oct 10, 2024 Cancer Clinical Metabolic Health Muscle Health

Nicotinamide Riboside Supplementation and Exercise Are Safe and Feasible in Childhood Cancer Survivors: Clinical Findings

Objectives

To evaluate the feasibility and efficacy of a remote telehealth exercise program, with or without NR supplementation, on improving glucose homeostasis and muscle health in adult childhood cancer survivors with prediabetes.

Journal

Pediatric Blood & Cancer

Key Outcomes

As a feasibility study, the target of achieving ≥70% compliance with both the exercise and NR interventions was successfully met, indicating that this approach was well-received by the patient population.
NR supplementation showed no significant effects on markers of glucose metabolism, body composition, or muscle strength.

Duration

6 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled, pilot study in 20 childhood cancer survivors with prediabetes

See Published Study

Cardiovascular Disease

NAD+ Metabolism and Heart Failure: Review

SynopsisNAD+, along with its reduced form NADH, is central to energy metabolism and is also the starting point for NADP+ production and a co-substrate for key enzymes that regulate oxidative stress...

Pharmacokinetic/Safety

Nicotinamide Riboside—Therapeutic Applications and Current State of Research: Review

SynopsisNicotinamide riboside (NR) is a form of vitamin B3 and a building block for NAD+, a coenzyme essential for energy production, DNA repair, and cell communication. NR has gained attention for...