Article: Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Apr 22, 2020 Clinical Inflammation Metabolic Health Muscle Health

Nicotinamide Riboside Supplementation Modestly Improves Body Composition & Sleeping Metabolic Rate: Clinical Findings

Objectives

To investigate the effects of NR supplementation on insulin sensitivity, mitochondrial function, and other metabolic health parameters in overweight and obese volunteers.

Journal

The American Journal of Clinical Nutrition

Key Outcomes

NR supplementation significantly increased markers of enhanced NAD+ metabolism in human skeletal muscle (e.g., NAAD and MeNam).
Minor beneficial changes in body composition, sleeping metabolic rate, and skeletal muscle acetyl-carnitine concentrations were found.

Duration

6 weeks

Dose

1000 mg

Study Design

Randomized, double-blind, placebo-controlled crossover study in 15 healthy, overweight or obese, sedentary men and women

See Published Study

Cancer

The Effects of Nutraceutical and Drug Cocktails in Duchenne Muscular Dystrophy: Preclinical Findings

Synopsis Duchenne muscular dystrophy (DMD) causes muscle weakness leading to respiratory failure. Earlier, quercetin showed temporary respiratory benefits in a mouse model. This study tested querc...

Neurological Health

Nicotinamide Riboside Partially Protects Neurons from TOP1-Linked Neurodegeneration and Extends Lifespan: Preclinical FIndings

Synopsis Topoisomerase 1 (TOP1) helps relieve DNA stress during gene transcription, especially for long genes critical to neuron function. Deleting TOP1 in mouse cortical and hippocampal neurons c...