Nicotinamide Riboside Supplementation Reduces Inflammation in Heart Failure Patients: Clinical Findings

Objectives

To investigate the mechanistic link between mitochondrial dysfunction and inflammatory activation in peripheral blood mononuclear cells (PBMCs), and the potential anti-inflammatory effect of boosting NAD+ levels.

Journal

Journal of Clinical Investigation

Key Outcomes

• NR supplementation increased whole blood NAD+ levels and mitochondrial respiration rate of the heart failure patients' PBMCs.
• NR reduced the production and gene expression of proinflammatory cytokines.
• The systemic inflammation in heart failure patients was causally linked to mitochondrial function of the PBMCs.

Duration

5-9 days

Dose

2000 mg

Study Design

Ex vivo and pilot clinical study in 5 Stage D heart failure patients