Nicotinamide Riboside Improves Ovarian Health and Fertility in Aging: Preclinical Findings

Synopsis

As female mice age, their ovaries lose follicles and the quality of eggs declines, partly due to lower levels of NAD+. In this study, supplementing aging mice with nicotinamide riboside (NR), a precursor to NAD+, increased ovarian NAD+ levels, improved egg quality, and boosted the number of follicles. NR also enhanced mitochondrial function, reduced oxidative stress, and decreased cellular abnormalities in eggs. Importantly, treated mice had higher ovulation rates and more live births. These findings suggest that NR could be a promising way to support ovarian health and fertility during aging.

Journal

Free Radical Biology and Medicine