Nicotinamide Riboside Protects Against Light-Induced Retinal Degeneration: Preclinical Findings

Synopsis

Retinal diseases cause a decline in nicotinamide adenine dinucleotide (NAD+), a vital coenzyme for cellular energy and biosynthesis, which may contribute to retinal damage. This study tested whether nicotinamide riboside (NR), an orally available NAD+ precursor safe for humans, can protect against light-induced retinal degeneration in mice. Mice received NR or a placebo before exposure to damaging light levels. Retinal function and structure were evaluated using electroretinography and imaging, while tissue was analyzed for cell death and inflammation. Light exposure reduced retinal NAD+ levels, impaired retinal function, damaged photoreceptor cells, and increased cell death and inflammation. NR treatment raised retinal NAD+ levels and prevented these harmful effects. This is the first study to show that NR protects against retinal degeneration in a mouse model, supporting further research on NR's potential clinical use to maintain retinal health.

Journal

Investigative Ophthalmology & Visual Science