Article: Nicotinamide Riboside Protects Against Obesity-Induced Atrial Fibrillation: Preclinical FIndings

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Cardiovascular Disease Cardiovascular Health Obesity Preclinical

Nicotinamide Riboside Protects Against Obesity-Induced Atrial Fibrillation: Preclinical FIndings

Synopsis

Aging and obesity increase the risk of atrial fibrillation (AF), a condition where the heart beats irregularly. Nicotinamide phosphoribosyltransferase (Nampt) produces NAD+, which is crucial for cell metabolism and redox balance, but both Nampt and NAD+ decline with age and obesity. In mice, a high-fat diet or partial Nampt deletion increased AF susceptibility, prolonged AF duration, and caused molecular changes in calcium handling. Supplementing with nicotinamide riboside, a NAD+ precursor, partially reversed these effects, showing that boosting the Nampt/NAD+ pathway can help protect against AF caused by obesity.

Journal

International Journal of Molecular Sciences

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