Article: Nicotinamide Riboside Reduces Neuroinflammation in Gulf War Illness: Preclinical Findings

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Neuroinflammation Neurological Health Preclinical

Nicotinamide Riboside Reduces Neuroinflammation in Gulf War Illness: Preclinical Findings

Synopsis

Gulf War Illness (GWI) affects about 30% of 1991 Gulf War veterans, causing fatigue, pain, and cognitive issues linked to mitochondrial dysfunction. Researchers found that veterans with GWI had lower NAD+ and Sirtuin 1 (Sirt1) levels—key regulators of energy metabolism and inflammation. In a mouse model of GWI, a two-month nicotinamide riboside (NR) supplementation restored NAD+ and Sirt1 levels, improved fatigue-related behavior, and reduced brain inflammation and oxidative stress. NR also enhanced mitochondrial function and activated protective pathways (NFκB and PGC-1α). These results suggest that NR supplementation may improve brain energy balance and reduce neuroinflammation in GWI, supporting further research into its use as a potential therapy for affected veterans.

Journal

NeuroToxicology

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