Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Objectives

To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy human subjects, and predict their impact on liver fat and metabolism.

Journal

Molecular Systems Biology

Key Outcomes

• CMA supplementation significantly decreased blood plasma levels of markers associated with increased liver fat, as well as blood plasma levels of branch chain amino acids.
• Mathematical modeling results showed a global increase in fat metabolism, decreased glucose metabolism, and increased synthesis of NAD+, carnitine, and glutathione.

Duration

5 days

Dose

1000 mg*
*A combination supplement consisting of 1 g NR, 20 g L-serine, 5 g N-acetyl-L-cysteine, and 3 g L-carnitine.

Study Design

Acute, single dose, 5-day pilot clinical study in 19 healthy men