Article: Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Clinical Liver Disease Liver Health

Nicotinamide Riboside Supplementation Combined with Metabolic Cofactors Shows Promise for NAFLD: Clinical Findings

Objectives

To assess the tolerability and metabolic effects of combined supplementation with combined metabolic activators (CMA), L-serine, NAC, nicotinamide riboside, and L-carnitine in healthy human subjects, and predict their impact on liver fat and metabolism.

Journal

Molecular Systems Biology

Key Outcomes

CMA supplementation significantly decreased blood plasma levels of markers associated with increased liver fat, as well as blood plasma levels of branch chain amino acids.
Mathematical modeling results showed a global increase in fat metabolism, decreased glucose metabolism, and increased synthesis of NAD+, carnitine, and glutathione.

Duration

5 days

Dose

1000 mg*
*A combination supplement consisting of 1 g NR, 20 g L-serine, 5 g N-acetyl-L-cysteine, and 3 g L-carnitine.

Study Design

Acute, single dose, 5-day pilot clinical study in 19 healthy men

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