Nicotinamide Riboside Improves Stroke Recovery by Modulating Monocyte Metabolism: Preclinical Findings

Synopsis Aging worsens post-stroke outcomes by amplifying neuroinflammation. This study examined whether older circulating monocytes exhibit altered metabolism after stroke and whether boosting NA...

Nicotinamide Riboside Counteracts Alcohol-Induced Neurotoxicity: Preclinical Findings

Synopsis Excessive alcohol intake causes cognitive impairment and neuronal injury driven by oxidative stress, inflammation, and profound mitochondrial dysfunction. This study shows that NRC, an NA...

Nicotinamide Riboside Blocks LPS-Induced Microglial Inflammation: Preclinical Findings

Synopsis In LPS-stimulated BV2 microglia, nicotinamide riboside (NR) restored mitochondrial function and reduced inflammation by activating the AMPK–SIRT3 signaling axis. NR shifted microglia from...

Nicotinamide Riboside Protects Against Brain Injury in Intracerebral Hemorrhage: Preclinical Findings

Synopsis Hemorrhagic stroke, caused by bleeding within the brain, is a severe condition with high disability and death rates. This study examined whether nicotinamide riboside (NR)—a vitamin B3–de...

Inhibiting CD38 and Boosting NAD+ with Nicotinamide Riboside Reduces Brain Inflammation: Preclinical Findings

SynopsisNeuroinflammation begins when the brain's innate immune system responds to inflammation. If not properly controlled, this inflammation worsens diseases like multiple sclerosis and Alzheimer...

Nicotinamide Riboside Reduces Neuroinflammation in Gulf War Illness: Preclinical Findings

Synopsis Gulf War Illness (GWI) affects about 30% of 1991 Gulf War veterans, causing fatigue, pain, and cognitive issues linked to mitochondrial dysfunction. Researchers found that veterans with G...

Maternal Nicotinamide Riboside Supplementation Supports Postpartum Recovery and Offspring Brain Health: Preclinical Findings

Synopsis Metabolic stress can disrupt the balance of NAD+ molecules in the body. Nicotinamide riboside (NR) helps restore NAD+ levels and protect against such stress. This study tested whether NAD...

Nicotinamide Riboside Reduces Inflammation and Supports Mitochondrial Health: Preclinical Findings

Synopsis Activation of the NLRP3 inflammasome, a key driver of inflammation linked to metabolic dysfunction, can be influenced by nutrient levels and mitochondrial health. In a study of healthy vo...