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Nicotinamide Riboside Alters Gut Microbiota to Reduce Weight Gain from High-Fat Diet in Mice: Preclinical Findings
Synopsis
The gut microbiome influences energy balance and obesity risk. Nicotinamide riboside (NR), a vitamin B3 form and NAD+ precursor, can reduce weight gain and increase energy use in obese mice. This study tested whether changes in gut bacteria contribute to NR's effects. Mice given NR had altered gut microbes, with more butyrate-producing bacteria linked to energy metabolism. Transferring feces from NR-treated mice to other obese mice reduced weight gain and boosted energy use. These findings suggest NR benefits partly come from changes in gut bacteria, which might enhance NR's therapeutic effects against obesity and related diseases.
Journal
mSystems