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Nicotinamide Riboside Supplementation Benefits in Early Parkinson's Disease: Clinical Findings
Objectives
To assess the safety, tolerability, and cerebral penetration of NR therapy in Parkinson's disease (PD) patients, as well as determine if NR has an impact on their neurometabolic profile and motor symptoms.
Journal
Cell Metabolism
Key Outcomes
- NR supplementation significantly increased cerebral NAD+ levels, altered brain metabolic pattern, and decreased levels of inflammatory cytokines in the cerebrospinal fluid of PD patients.
- Moreover, patients experienced a mild but significant clinical improvement, and this correlated with the change in the brain's metabolic pattern.
Duration
30 days
Dose
1000 mg
Study Design
Randomized, double-blind, placebo-controlled, phase I study in 30 Parkinson's disease (PD) patients