Article: DNA Replication Stress Causes Complex Metabolic Changes: Preclinical Findings

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Metabolic Health Preclinical

DNA Replication Stress Causes Complex Metabolic Changes: Preclinical Findings

Synopsis

DNA replication stress occurs when cells struggle to copy damaged DNA, affecting metabolism. Using mice lacking the DNA polymerase Rev1, researchers observed sex-specific metabolic changes: females gained more fat and had glucose intolerance, while males had different activity levels. Females showed signs of poor aerobic metabolism and more reliance on anaerobic glycolysis. Giving nicotinamide riboside (NR) to boost aerobic metabolism did not fix these issues. This suggests that DNA replication stress leads to complex metabolic problems not easily reversed by NAD+ supplementation.

Journal

American Journal of Physiology-Endocrinology and Metabolism

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Muscle Health

Effects of Nicotinamide Riboside on Spinal and Bulbar Muscular Atrophy (SBMA): Preclinical Findings

SynopsisPrevious studies have shown that in spinal and bulbar muscular atrophy (SBMA), a mutant protein called polyQ-expanded AR becomes improperly acetylated, and activating SIRT1, an NAD-dependen...

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Neurological Health

Effects of Nicotinamide Riboside on Mitochondrial Health and Dopamine in Parkinson's Disease: Preclinical Findings

SynopsisParkinson's disease (PD) involves mitochondrial dysfunction, reduced proteasome activity, and dopamine depletion. NR activated mitochondrial function in C. elegans, rescuing α-synuclein-rel...

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