Article: DNA Replication Stress Causes Complex Metabolic Changes: Preclinical Findings

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Metabolic Health Preclinical

DNA Replication Stress Causes Complex Metabolic Changes: Preclinical Findings

Synopsis

DNA replication stress occurs when cells struggle to copy damaged DNA, affecting metabolism. Using mice lacking the DNA polymerase Rev1, researchers observed sex-specific metabolic changes: females gained more fat and had glucose intolerance, while males had different activity levels. Females showed signs of poor aerobic metabolism and more reliance on anaerobic glycolysis. Giving nicotinamide riboside (NR) to boost aerobic metabolism did not fix these issues. This suggests that DNA replication stress leads to complex metabolic problems not easily reversed by NAD+ supplementation.

Journal

American Journal of Physiology-Endocrinology and Metabolism

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