Effect of the Mediterranean Diet Supplemented with Nicotinamide Riboside, Pterostilbene, and/or Coconut Oil in ALS Patients: Pilot Clinical Findings

Objectives

To assess the effects of a Mediterranean diet supplemented with nicotinamide riboside (NR) and pterostilbene, with or without coconut oil, on body weight, composition, BMI, and overall body shape in patients with amyotrophic lateral sclerosis (ALS).

Journal

Frontiers in Nutrition

Key Outcomes

• The Mediterranean diet with NRPT supplementation resulted in a significant increase in muscle mass percentage and a reduction in fat mass percentage. This group also showed a decrease in fat at the triceps, upper hip bone, and abdomen.
• The ketogenic Mediterranean diet with coconut oil led to similar improvements, with significant increases in muscle mass percentage and reductions in fat, particularly under the shoulder blade and abdomen.
• The ketogenic Mediterranean diet with NRPT and coconut oil also significantly increased muscle mass percentage and reduced abdominal fat.
• Overall, the Mediterranean diet with NRPT and the Mediterranean diet supplemented with coconut oil were the most effective nutritional interventions, yielding the greatest improvements in body composition among ALS patients.

Duration

4 months

Dose

15 mg NR + 2.5 mg/kg PT

Study Design

Prospective, randomized, mixed, analytical, and experimental pilot study in 40 patients with ALS