Article: Nicotinamide Riboside and Phycocyanin Oligopeptides Reduce Stress-Induced Cellular Aging: Preclinical Findings

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Cellular Health Healthy Aging & Longevity Inflammation Preclinical

Nicotinamide Riboside and Phycocyanin Oligopeptides Reduce Stress-Induced Cellular Aging: Preclinical Findings

Synopsis

Chronic stress accelerates cellular aging and increases inflammation and oxidative damage, but certain nutrients may help protect against these effects. In this study, researchers tested nicotinamide riboside (NR)—a vitamin B3 derivative that boosts NAD+—and phycocyanin oligopeptide (PC), an antioxidant compound from blue-green algae, in stressed rats. Individually and especially together, NR and PC improved antioxidant defenses, reduced inflammatory cytokines like IL-6 and TNF-α, and increased NAD+ levels in the liver. They also lengthened telomeres, the protective caps on chromosomes that shorten with stress and aging, while restoring SIRT1, SIRT3, and NAMPT—key proteins for metabolism and cellular repair. These findings suggest that combining NR with antioxidant-rich nutrients like PC may help combat stress-induced aging, inflammation, and metabolic decline, though more research is needed in humans.

Journal

Antioxidants

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