Article: Nicotinamide Riboside Protects Against Ionizing Radiation-Induced Aging: Preclinical Findings

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Cellular Health Healthy Aging & Longevity Preclinical

Nicotinamide Riboside Protects Against Ionizing Radiation-Induced Aging: Preclinical Findings

Synopsis

Radiation therapy effectively kills cancer cells but can also damage healthy tissues, leading to premature aging and long-term side effects in survivors. In this study, researchers used a mouse model of radiation-induced aging to test whether nicotinamide riboside (NR)—a vitamin B3 derivative that boosts NAD+—could protect against these effects. Mice exposed to radiation showed signs of hematopoietic system aging, including a weakened spleen, impaired stem cell regeneration, and metabolic dysfunction. NR supplementation reversed these aging signs by reducing cellular senescence, improving blood metabolism, and restoring the balance and regenerative ability of hematopoietic stem cells. Mechanistically, NR reduced oxidative stress (ROS) and suppressed the GCN2/eIF2α/ATF4 stress pathway, which is overactivated by radiation. These findings suggest that NR could be a promising therapy to protect radiation-exposed patients and cancer survivors from premature aging and immune decline.

Journal

Aging Cell

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Cardiovascular Health

Nicotinamide Riboside and Nicotinamide Mononucleotide Prevent Oxidative Stress in Blood Vessel Cells From COVID-19 Patients: Preclinical Findings

SynopsisCOVID-19 is associated with vascular endothelial dysfunction, but mechanisms remain unclear. This study exposed human aortic endothelial cells (HAECs) to plasma from hospitalized COVID-19 p...

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Case Study

Clinical Outcomes of SAMe and Nicotinamide Riboside Supplementation in a Child with Arts Syndrome: Case Report

Objectives To examine the effects of supplementation of S-adenosylmethionine (SAMe) and NR in a child with Arts syndrome and compare to previous Arts syndrome patients who received SAMe with or wi...

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