Article: Nicotinamide Riboside Supplementation Improves Motor Coordination and Eye Movements in Children with Ataxia Telangiectasia: Clinical Findings

Oct 29, 2023 Ataxia Telangiectasia Clinical Neurological Health

Nicotinamide Riboside Supplementation Improves Motor Coordination and Eye Movements in Children with Ataxia Telangiectasia: Clinical Findings

Objectives

To examine the safety and efficacy of long-term NR supplementation on neuromotor function in patients with ataxia telangiectasia (AT).

Journal

Movement Disorders

Key Outcomes

Long-term NR supplementation was safe and well tolerated, with no serious adverse events.
Compared to historical controls, NR supplementation significantly improved motor coordination and eye movements in AT patients.
This is the second clinical NR trial including children under the age of 18 and the longest NR supplementation study to date.

Duration

2 years

Dose

500 mg

Study Design

Open-label, single arm, observational intervention study in 10 patients with ataxia telangiectasia (AT)

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