Article: Nicotinamide Riboside Protects Spinal Cord Tissue and Recovery After Injury: Preclinical Findings

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Neurological Health Preclinical

Nicotinamide Riboside Protects Spinal Cord Tissue and Recovery After Injury: Preclinical Findings

Synopsis

After a spinal cord injury (SCI), tissue damage continues to spread beyond the original site, worsening nerve loss and impairing movement. One major factor driving this damage is the rapid depletion of NAD+, a key molecule needed for cellular energy, DNA repair, and tissue recovery. This study tested whether nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, could protect the spinal cord and improve healing in rats. Administering NR before and after the injury doubled NAD+ levels in the spinal cord and significantly reduced nerve and tissue loss, especially in neurons and axons. Treated rats showed better motor coordination and walking ability compared to untreated ones. The results demonstrate that restoring NAD+ with NR can help limit spinal cord damage, preserve nerve function, and support recovery after injury.

Journal

Experimental Neurology

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