Nicotinamide Riboside Mitigates Oxidative Damage and Fibrosis in Trabecular Meshwork Cells: Preclinical Findings

Synopsis Glaucoma is a leading cause of irreversible blindness, often caused by dysfunction and scarring in the trabecular meshwork (TM)—the eye tissue that regulates fluid drainage and intraocula...

Nicotinamide Riboside–Mediated Cardioprotection Depends on Insulin Signaling and Glycolytic Metabolism: Preclinical Findings

Synopsis Low levels of nicotinamide adenine dinucleotide (NAD+) contribute to heart diseases, aging, and ischemia-reperfusion injury (IRI)—the tissue damage that occurs when blood supply returns t...

Comparative Evaluation of Four NAD+ Precursors in Preventing High-Glucose-Induced Hepatocyte Damage: Preclinical Findings

Synopsis Boosting NAD+ levels is known to protect the liver from metabolic stress, but the effectiveness of different NAD+ precursors—nicotinic acid (NA), niacinamide (NAM), nicotinamide riboside ...

Nicotinamide Riboside Restores NAD+ Levels and Improves Metabolism in Diastolic Heart Failure: Preclinical Findings

Synopsis Heart failure with left ventricular diastolic dysfunction is a growing health problem worldwide. This study looked at levels of NAD+, a key metabolic cofactor, in the hearts of patients w...

Liposome Encapsulation Improves Brain Delivery and Neuroprotective Efficacy of Nicotinamide Riboside in Cerebral Ischemia: Preclinical Findings

Synopsis Although nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, has proven neuroprotective effects, its poor ability to cross the blood–brain barrier limits its effectiveness in...

Nicotinamide Riboside Slows Intervertebral Disc Degeneration: Preclinical Findings

Synopsis Intervertebral disc degeneration (IVDD) is a common age-related condition that causes chronic back pain and reduced mobility. This study investigated how nicotinamide riboside (NR)—a vita...

Nicotinamide Riboside Reduces Colitis Severity in Inflammatory Bowel Disease: Preclinical Findings

Synopsis The gut microbiome produces thousands of metabolites—small molecules that influence inflammation, immunity, and disease. To better understand their roles in inflammatory bowel disease (IB...

Nicotinamide Riboside Protects Against Myocardial Ischemia/Reperfusion Injury: Preclinical Findings

Synopsis Myocardial ischemia-reperfusion (I/R) injury—tissue damage caused when blood flow returns to the heart after a period of oxygen deprivation—can worsen heart attacks and lead to lasting ca...

Effects of Nicotinamide Riboside on Spinal and Bulbar Muscular Atrophy (SBMA): Preclinical Findings

SynopsisPrevious studies have shown that in spinal and bulbar muscular atrophy (SBMA), a mutant protein called polyQ-expanded AR becomes improperly acetylated, and activating SIRT1, an NAD-dependen...

Nicotinamide Riboside Ameliorates Senescence-Associated Alterations in Gastric Parietal Cells: Preclinical Findings

Synopsis Aging causes widespread cellular decline, including in the gastrointestinal (GI) tract, where reduced digestive function and nutrient absorption often occur. This study examined how aging...

Comparative Analysis of Nicotinamide Mononucleotide and Nicotinamide Riboside in Protecting HeLa Cells From Cisplatin-Induced DNA Damage: Preclinical Findings

Synopsis Cisplatin, a common chemotherapy drug, works by damaging DNA in cancer cells—but it can also harm healthy cells, leading to side effects. This study compared two vitamin B3–derived NAD+ p...

Nicotinamide Riboside Attenuates Inflammation and Promotes Functional Recovery After Spinal Cord Injury: Preclinical Findings

Synopsis After a spinal cord injury (SCI), levels of nicotinamide adenine dinucleotide (NAD+)—a vital molecule for energy metabolism and cell repair—drop significantly, contributing to inflammatio...

Nicotinamide Riboside Restores Mitochondrial Function in Alpers’ Syndrome: Preclinical Findings

SynopsisAlpers' syndrome is a devastating early-onset neurodegenerative disorder caused by POLG mutations impairing mitochondrial DNA replication. Patient-derived iPSCs were used to create brain or...

Nicotinamide Riboside and Nicotinamide Mononucleotide Restore Nerve Function in Diabetic Neuropathy: Preclinical Findings

SynopsisReduced NAD+ signaling contributes to nerve degeneration in diabetic peripheral neuropathy. Researchers tested NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, in cul...

Nicotinamide Riboside Reverses Pulmonary Hypertension: Preclinical Findings

Synopsis Pulmonary hypertension (PH) is a deadly lung vascular disease caused by endothelial dysfunction and vascular remodeling that strain the heart. This study identified Sirtuin 7 (SIRT7)—a NA...

Nicotinamide Riboside Reverses Metabolic Dysfunction in Werner's Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) features premature aging and metabolic dysfunction, yet mechanisms remain unclear. This study found that loss of the WRN protein accelerates early fat cell formation in...

Nicotinamide Riboside Boosts NAD+, to Reduce Sleep Need and Support Brain Energy: Preclinical Findings

SynopsisNon-rapid eye movement sleep (NREMS) is linked to lower brain glucose use, which slows metabolic reactions involving NAD+. This study tested whether boosting NAD+ with nicotinamide riboside...

Combination Therapy with Nicotinamide Riboside, Pterostilbene, and Ibudilast Protects Motor Neurons and Prolongs Survival in ALS: Preclinical Findings

Synopsis Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease marked by oxidative stress, inflammation, and the progressive death of motor neurons. This study tested a triple t...

NAMPT Inhibition in Neuroendocrine Cancers and the Role of NAD+ Precursors: Preclinical Findings

Synopsis Nicotinamide phosphoribosyltransferase (NAMPT) is a key enzyme that helps cancer cells make NAD+, a molecule essential for energy production and survival. Drugs that block NAMPT (NAMPT in...

Nicotinamide Riboside Restores Sperm Production and Male Fertility: Preclinical Findings

Synopsis Male infertility is a widespread issue, and one cause may be mutations in the BNC1 gene, which is crucial for sperm development. This study found that mice with a Bnc1 mutation showed spe...