Article: Nicotinamide Riboside and Nicotinamide Mononucleotide Restore Nerve Function in Diabetic Neuropathy: Preclinical Findings

PrevNext
Diabetes Neurological Health Neuropathy Preclinical

Nicotinamide Riboside and Nicotinamide Mononucleotide Restore Nerve Function in Diabetic Neuropathy: Preclinical Findings

Synopsis

Reduced NAD+ signaling contributes to nerve degeneration in diabetic peripheral neuropathy. Researchers tested NAD+ precursors, nicotinamide riboside and nicotinamide mononucleotide, in cultured neurons and diabetic mice. Both precursors increased NAD+ and SIRT1 activity, promoting neurite growth in neurons. In diabetic mice, NR and NMN improved sensory function, restored nerve conduction, and preserved intraepidermal nerve fibers. The benefits were dependent on SIRT1, highlighting NAD+ supplementation or SIRT1 activation as promising strategies to treat DPN.

Journal

International Journal of Molecular Sciences

Share

Read more

Neurological Health

Nicotinamide Riboside Boosts NAD+, to Reduce Sleep Need and Support Brain Energy: Preclinical Findings

SynopsisNon-rapid eye movement sleep (NREMS) is linked to lower brain glucose use, which slows metabolic reactions involving NAD+. This study tested whether boosting NAD+ with nicotinamide riboside...

Read more
Healthy Aging & Longevity

Nicotinamide Riboside Boosts NAD+ to Improve Telomere Stability: Preclinical Findings

SynopsisTelomere biology disorders (TBDs), such as dyskeratosis congenita (DC), are characterized by critically short telomeres and often lead to bone marrow failure. A key metabolic molecule, NAD+...

Read more