Structural Insights Into Nicotinamide Riboside Kinase Reveal How Cells Make NAD+: Preclinical Findings

Synopsis The nicotinamide riboside kinase (Nrk) pathway, active in eukaryotic cells, plays a vital role in converting nicotinamide riboside into nicotinamide adenine dinucleotide (NAD⁺), an essent...

SIRT1 Activators Like Nicotinamide Riboside Prevent Neuron Damage in Mouse Model of Multiple Sclerosis: Preclinical Findings

Synopsis Axonal damage and neuron loss contribute to permanent vision loss and neurological disability in optic neuritis and multiple sclerosis (MS). Current treatments mainly target inflammation ...

Boosting NAD+ Production Protects Nerves and Slows Axon Degeneration After Injury: Preclinical Findings

Synopsis Axonal degeneration, a major cause of nerve damage in neurodegenerative diseases and after traumatic injury, is a self-destructive process separate from normal cell death. Previous studie...

Nicotinamide Riboside Boosts NAD+ and Extends Lifespan in Yeast: Preclinical Findings

Synopsis In yeast, NAD+ is essential for the activity of Sir2, a protein linked to longevity. Previous studies showed that changing NAD+ precursors could affect aging, but none extended lifespan. ...

Discovery of Nicotinamide Riboside as a Natural NAD+ Precursor in Humans and Yeast: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is a vital molecule required by all living organisms. It functions both as a coenzyme that supports energy-producing reactions and as a source of ...