Nicotinamide Riboside Attenuates NASH Progression: Preclinical Findings

Synopsis Non-alcoholic steatohepatitis (NASH) is a severe form of fatty liver disease driven by oxidative stress and inflammation. This study investigated whether increasing NADPH, a key molecule ...

Nicotinamide Riboside Improves Mitochondrial Function and Survival Post-Heart Attack: Preclinical Findings

SynopsisMyocardial infarction (MI), or heart attack, is a leading cause of death, and reduced NAD+ levels in the heart can worsen damage after MI. This study tested whether nicotinamide riboside (N...

Role of nadR Gene in Growth and Virulence of Streptococcus suis Bacteria: Preclinical Findings

SynopsisStreptococcus suis serotype 2 (SS2) is a harmful bacterium in pigs that can also infect humans. This study investigated the role of the nadR gene, which helps make and transport NAD+ inside...

Raising NAD+ via Nicotinamide Riboside Enhances Heart Function in Heart Failure: Preclinical Findings

SynopsisBoosting cellular NAD⁺ levels has been shown to prevent heart problems in various models of heart failure, but how it works at the molecular level is not fully understood. Most studies focu...

Maternal Nicotinamide Riboside Protects Against Cardiac Mitochondrial Dysfunction and Supports Fetal Growth: Preclinical Findings

SynopsisGestational hypoxia reduces fetal growth and impairs heart and placental mitochondrial function, partly by limiting NAD+ and energy production. In this study, pregnant guinea pigs were expo...

Nicotinamide Riboside Improves Dental Stem Cell Regeneration: Preclinical Findings

Synopsis Human dental pulp stem cells (hDPSCs) are responsible for repairing and regenerating the inner tooth structure known as the pulp-dentin complex, but their ability to form new dentin is of...

Nicotinamide Riboside and Resveratrol Rejuvenate Stem Cells and Enhance Bone Regeneration in Aging: Preclinical Findings

Synopsis Age-related bone loss is a major cause of disability in older adults, largely due to the aging and dysfunction of bone marrow mesenchymal stem cells (MSCs)—the cells responsible for bone ...

Nicotinamide Riboside Improves Inflammation-Induced Chronic Pain | Preclinical Findings

Synopsis Many patients continue to feel pain even after inflammation has healed, but the reason has been unclear. This study found that mitochondrial dysfunction in sensory neurons—the nerve cells...

Nicotinamide Riboside Ameliorates Joint Damage and Inflammation in Knee Osteoarthritis: Preclinical Findings

Synopsis Knee osteoarthritis (KOA) is a common condition that causes joint pain and stiffness due to cartilage breakdown and inflammation. This study compared the effects of nicotinamide riboside ...

Nicotinamide Riboside Maintains Spermatogonial Stem Cell Function and DNA Integrity: Preclinical Findings

Synopsis Tree shrews, small mammals closely related to primates, are valuable models for biomedical and genetic research. Scientists previously developed a spermatogonial stem cell (SSC) gene-edit...

Nicotinamide Riboside and Phycocyanin Oligopeptides Reduce Stress-Induced Cellular Aging: Preclinical Findings

Synopsis Chronic stress accelerates cellular aging and increases inflammation and oxidative damage, but certain nutrients may help protect against these effects. In this study, researchers tested ...

Nicotinamide Riboside Defends Against Sulfur Mustard-Related Toxicity: Preclinical Findings

Synopsis Sulfur mustard (SM) and related chemicals are toxic compounds that damage DNA by depleting NAD+, a molecule essential for DNA repair and energy balance. This study examined whether restor...

Effects of Nicotinamide Riboside on Bacterial Respiratory Epithelial Infections: Preclinical Findings

Synopsis This study found that during infection, lung cells experience a breakdown in the NAD+ salvage pathway, which reduces NAD+ production—a molecule crucial for energy metabolism and immune de...

Genetic Background Influences Nicotinamide Riboside Response in Barth Syndrome: Preclinical Findings

SynopsisBarth Syndrome is a rare genetic disorder caused by mutations in the TAFAZZIN (TAZ) gene, which affects mitochondrial function by disrupting cardiolipin remodeling. While clinical trials ar...

Effects of Increasing NAD+ on the Pluripotency of Stem Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is vital for cellular energy and signaling, and recent studies suggest it may influence how embryonic stem cells maintain their ability to become ...

Nicotinamide Riboside Restores Intestinal Health and Mitochondrial Function in Colitis: Preclinical Findings

SynopsisReduced levels of PGC1α, a key regulator of cellular energy, contribute to inflammatory bowel disease (IBD). In both mice with experimental colitis and humans with ulcerative colitis, NAD+ ...

Nicotinamide Riboside Protects Against Ionizing Radiation-Induced Aging: Preclinical Findings

Synopsis Radiation therapy effectively kills cancer cells but can also damage healthy tissues, leading to premature aging and long-term side effects in survivors. In this study, researchers used a...

Nicotinamide Riboside and Nicotinamide Mononucleotide Prevent Oxidative Stress in Blood Vessel Cells From COVID-19 Patients: Preclinical Findings

SynopsisCOVID-19 is associated with vascular endothelial dysfunction, but mechanisms remain unclear. This study exposed human aortic endothelial cells (HAECs) to plasma from hospitalized COVID-19 p...

Nicotinamide Riboside Protects Retinal Nerve Cells in Glaucoma: Preclinical Findings

SynopsisGlaucoma causes progressive retinal ganglion cell (RGC) degeneration and vision loss, often associated with elevated intraocular pressure (IOP). This study tested whether oral administratio...

Using Engineered Cancer Cells to Identify How Orphan Cytotoxins Work: Preclinical Findings

Synopsis Orphan cytotoxins are small molecules whose exact targets or mechanisms are unknown. Understanding how they work can reveal new research tools and potential therapies. To help identify th...