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Nicotinamide Riboside Ameliorates Senescence-Associated Alterations in Gastric Parietal Cells: Preclinical Findings
Synopsis
Aging causes widespread cellular decline, including in the gastrointestinal (GI) tract, where reduced digestive function and nutrient absorption often occur. This study examined how aging affects gastric parietal cells—the stomach cells responsible for producing acid—and whether nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, could protect them. Older rats showed typical signs of cellular senescence, including reduced NAD+ levels, oxidative stress, DNA damage, and increased cell death, all of which impaired parietal cell structure and function. After three weeks of daily NR supplementation, aged rats had higher NAD+ levels, improved cellular structure, increased anti-apoptotic (Bcl-2) activity, and restored gastrin and pepsinogen-I secretion—both key to normal digestion. These findings suggest that NR can reverse aging-related stomach cell degeneration, enhance energy metabolism, and potentially prevent digestive decline and anemia associated with aging.
Journal
Egyptian Journal of Histology