Low NMNAT2 Triggers SARM1 Activity and Alters Nicotinamide Riboside Response in Axons: Preclinical Findings

SynopsisNMNAT2 is a key protein that keeps axons healthy by blocking the pro-degenerative protein SARM1. Completely losing NMNAT2 in mice causes severe axon loss and early death, but removing SARM1...

Effects of Nicotinamide Riboside on Hearing: Preclinical Findings

Synopsis This study examined how repeated high-dose intravenous nicotinamide riboside (NR)—a vitamin B3–derived NAD+ booster—affects hearing in Wistar rats. Researchers measured the activity of bo...

Nicotinamide Riboside Enhances T Cell Function and Antitumor Immunity: Preclinical Findings

Synopsis Most current cancer immunotherapies mainly focus on activating type 1 immune responses, which help fight cancer, but long-term remission is rare. Our study shows that a type 2 immune prot...

Nicotinamide Riboside Prevents Cardiac Death: Preclinical Findings

Synopsis This study revealed that maintaining NAD+ levels is critical for heart health and rhythm stability. Researchers found that when Nampt, the key enzyme responsible for NAD+ production, was ...

Nicotinamide Riboside Restores NAD+ and Reduces Fatty Liver Damage: Preclinical Findings

Synopsis Palmitic acid, the most common saturated fat in the blood, can cause liver inflammation, fat accumulation (steatosis), and cellular damage. This study explored how such fatty acids disrup...

Nicotinamide Riboside Protected Muscle Cells from Heat-Induced Injury: Preclinical Findings

Synopsis Prolonged exposure to heat stress can damage skeletal muscle (SKM) by disrupting mitochondrial function, but the mechanisms behind this injury are not fully understood. This study found t...

Altering the NAD+/NADH Ratio in Reprograms the Metabolome in Glioblastoma: Preclinical Findings

Synopsis Glioblastoma multiforme (GBM) is the most aggressive and deadly form of brain cancer, known for its rapid growth and invasion into surrounding tissue. Because GBM cells rewire their metab...

NAD+ Supports Metabolism in Impaired Urea Cycle: Preclinical Findings

SynopsisProblems in the urea cycle and how they relate to obesity and inflammation are not well understood, partly because classical urea cycle defects are severe and dramatic. To study this, resea...

Fluorinated NR Enhances NAD+ Depletion in Glioblastoma Therapy: Preclinical Findings

Synopsis Glioblastoma is one of the most aggressive and treatment-resistant brain cancers, partly because its cells rely heavily on NAD+, a molecule vital for energy production and survival. The d...

Nicotinamide Riboside Supports Brain Health and Reduces Inflammation in Alzheimer’s Disease: Preclinical Findings

SynopsisNicotinamide riboside (NR), a precursor of NAD+, can improve cognitive function and reduce brain inflammation in Alzheimer's disease (AD) mouse models, even without affecting beta-amyloid p...

NAD+ Precursor Supplementation Enhances Metabolic Efficiency and Antibody Production: Preclinical Findings

Synopsis This study explored how NAD+ precursors can enhance productivity in Chinese hamster ovary (CHO) cells, which are widely used to produce therapeutic antibodies. Previous research showed th...

Nicotinamide Riboside Restores NAD+ and Improves Mitochondrial Function in HIV-Nephropathy: Preclinical Findings

SynopsisHIV disease remains prevalent in the United States and especially in sub-Saharan Africa. In mice with HIV-associated kidney disease (HIVAN), their kidney cells showed mitochondrial dysfunct...

Nicotinamide Riboside Protects the Heart from Blood Flow Injury: Preclinical Findings

SynopsisMyocardial ischemia-reperfusion (I/R) injury damages the heart when blood flow returns to previously blocked tissue, causing oxidative stress, inflammation, and cell death. This study teste...

Nicotinamide Riboside Prevents Chemotherapy-Induced Peripheral Neuropathy: Preclinical Findings

Synopsis Paclitaxel (PTX) is a widely used chemotherapy drug for cancers such as breast, lung, and ovarian cancer, but one of its major side effects is chemotherapy-induced peripheral neuropathy (...

NAD+ Precursors Restore Mitophagy and Reverse Aging Markers: Preclinical Findings

SynopsisSelective removal of damaged mitochondria (mitophagy) is crucial for cell health. Human cells show active basal mitophagy, mediated by the PINK1/Parkin pathway and p62 as a receptor. Mitoph...

NMRK2 Serves as a Diagnostic Biomarker for Renal Cell Carcinoma: Preclinical Findings

Synopsis Xp11.2 translocation renal cell carcinoma (tRCC) is a rare and aggressive form of kidney cancer that currently lacks reliable diagnostic tools and effective treatments. This study identif...

Nicotinamide Riboside Prevents Muscle Fatigue in Pigs: Preclinical Findings

SynopsisThis study tested how different doses of nicotinamide riboside (NR) affect muscle fatigue in pigs. One hundred barrows were fed diets with 0, 15, 30, or 45 mg NR per kg of body weight, or g...

Nicotinamide Riboside Helps Improve Symptoms in Lupus: Preclinical Findings

SynopsisThe protein PPP2R2A helps regulate the immune system, and in lupus-prone mice, T cells lacking this protein caused less autoimmunity and kidney damage. Without PPP2R2A, T cells produced mor...

Nicotinamide Riboside Extends Lifespan and Restores Cardiac Function in Friedreich’s Ataxia: Preclinical Findings

Synopsis Friedreich’s ataxia (FRDA) is a rare inherited disease caused by reduced production of frataxin, a mitochondrial protein essential for iron-sulfur cluster formation. The condition leads t...

Nicotinamide Riboside Protects Against Radiation-Induced Intestinal Senescence: Preclinical Findings

Synopsis Radiation therapy for cancer often damages the intestines, leading to long-term side effects known as delayed effects of acute radiation exposure (DEARE). This study investigated whether ...