Nicotinamide Riboside Reduces Oxidative Stress in Alzheimer's Disease: Preclinical Findings

Synopsis Mitophagy—the process by which damaged mitochondria are removed—is essential for maintaining brain cell health and preventing neurodegeneration. In this study, researchers examined fibrob...

Nicotinamide Riboside Protects Mitochondria in Aging Kidneys: Preclinical Findings

SynopsisAs kidneys age, their cells, especially in the distal tubules, undergo changes in mitochondrial structure and function, but little is known about how aging or anti-aging interventions affec...

Effects of Nicotinamide Riboside on Lung Cells: Preclinical Findings

Synopsis This study examined how different concentrations of nicotinamide riboside (NR)—a vitamin B3–derived NAD+ precursor—affect human lung cells grown in both 2D and 3D cultures. Researchers fo...

Nicotinamide Riboside Protects Against Brain Injury in Intracerebral Hemorrhage: Preclinical Findings

Synopsis Hemorrhagic stroke, caused by bleeding within the brain, is a severe condition with high disability and death rates. This study examined whether nicotinamide riboside (NR)—a vitamin B3–de...

Effects of Nicotinamide Riboside on Mitochondrial Health and Dopamine in Parkinson's Disease: Preclinical Findings

SynopsisParkinson's disease (PD) involves mitochondrial dysfunction, reduced proteasome activity, and dopamine depletion. NR activated mitochondrial function in C. elegans, rescuing α-synuclein-rel...

Nicotinamide Riboside Protects Against Maternal Acetaminophen Exposure: Preclinical Findings

Synopsis Acetaminophen (APAP) is widely used by pregnant women to relieve pain and fever, but recent evidence suggests it may harm fetal development, especially during the sensitive period of egg ...

Nicotinamide Riboside Preserves Retinal Cells and Mitochondrial Function in Glucocorticoid-Induced Glaucomae: Preclinical Findings

SynopsisGlucocorticoid-induced glaucoma (GIG) is a common side effect of steroid use that can cause blindness by damaging the eye's trabecular meshwork (TM), raising eye pressure, and killing retin...

Nicotinamide Riboside Promotes Spinal Cord Repair: Preclinical Findings

Synopsis Repairing the spinal cord after injury is extremely difficult because nerve cells do not easily regenerate. One promising strategy is to activate endogenous neural stem cells (NSCs)—the b...

Nicotinamide Riboside Improves Survival and Motor Function in Parkinson’s Disease: Preclinical Findings

Synopsis Parkinson’s disease (PD) is a neurodegenerative disorder marked by the loss of dopamine-producing neurons, leading to motor dysfunction and other symptoms. This study investigated how nic...

A Novel Ketogenic Diet Reduces Seizure Severity and Prevents Fatty Liver in Epileptogenesis: Preclinical Findings

Synopsis Drug-resistant epilepsy remains difficult to manage, and while the ketogenic diet (KD) can help reduce seizures, its high fat content often causes metabolic side effects and poor patient ...

Targeting Autophagy-NAD Pathway Protects Cells in Niemann-Pick Type C1 Disease: Preclinical Findings

SynopsisImpaired autophagy, which leads to the buildup of misfolded proteins and damaged organelles, has been linked to many human diseases. Loss of autophagy in metabolically active cells can caus...

In Ovo Nicotinamide Riboside Feeding Increases Muscle Mass and Fiber Number in Broiler Chickens: Preclinical Findings

SynopsisThis study examined the effects of in ovo nicotinamide riboside (NR) feeding on growth and meat quality in high-yield broilers. Fertilized Cobb 700 eggs were randomly assigned to four treat...

Therapeutic Effects of Nicotinamide Riboside and NMN on Nonalcoholic Fatty Liver Disease (NAFLD): Preclinical Findings

Synopsis This study explored how nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN)—two vitamin B3–derived NAD+ precursors known for their anti-aging and metabolic benefits—affect th...

Nicotinamide Riboside Protects Mitochondria and Mitigates Brain Dysfunction in Chronic Cerebral Hypoperfusion: Preclinical Findings

Synopsis Chronic cerebral hypoperfusion (CCH)—a long-term reduction in blood flow to the brain—is a major cause of vascular dementia (VaD), which leads to memory loss and cognitive decline. This s...

Nicotinamide Riboside Reduces Photo-Induced Hyperpigmentation in Skin Cells: Preclinical Findings

Synopsis Ultraviolet radiation (UVR) from sunlight is a major environmental factor that causes skin damage, including sunburn, DNA damage, premature aging, and hyperpigmentation. This study explor...

Nicotinamide Riboside Prevents Nicotine and Coca-Cola™-Induced Fatty Liver: Preclinical Findings

Synopsis Both nicotine—found in cigarettes and e-cigarettes—and high-fructose corn syrup (HFCS)—a sweetener in many soft drinks—are known to harm liver health. This study tested whether combining ...

Nicotinamide Mononucleotide and Nicotinamide Riboside Rejuvenate Ovarian Function: Preclinical Findings

Synopsis As women age, their ovarian function and egg quality decline, partly due to mitochondrial dysfunction—an imbalance between mitochondrial fission and fusion that leads to energy stress and...

Effects of Intravenous Nicotinamide Riboside on Doxorubicin-Related Organ Damage: Preclinical Findings

Synopsis Doxorubicin (DOX) is a powerful chemotherapy drug used to treat various cancers, but its use is limited by serious side effects that damage vital organs such as the heart, kidneys, liver,...

Nicotinamide Riboside and Pterostilbene Prevent UVB-Induced Skin Swelling and Immune Suppression: Preclinical Findings

Synopsis Exposure to ultraviolet B (UVB) radiation can cause skin inflammation, immune suppression, and long-term risks like skin cancer. This study tested whether nicotinamide riboside (NR), a vi...

Nicotinamide Riboside and Resveratrol Promote Diabetic Wound Healing: Preclinical Findings

Synopsis Diabetic skin ulcers are difficult to treat and often lead to severe complications like infection or amputation. This study investigated how nicotinamide riboside (NR)—a vitamin B3–derive...