Urolithin A and Nicotinamide Riboside Support Brain Immune Cells and Mitochondrial Health: Preclinical Findings

SynopsisDuring aging, many cellular processes, including DNA repair, energy production, and immune function, become less efficient. This study examined how two natural compounds, Urolithin A (UA) a...

Unstable NAD+ Metabolism Leads to Impaired Heart Mitochondrial Function: Preclinical Findings

SynopsisPoly(ADP-ribose) polymerase (PARP) enzymes repair DNA but use NAD+ as fuel. Excessive DNA damage in heart cell mitochondria can overactivate PARP, depleting NAD+ and impairing mitochondrial...

Unique Mutations in Mouse Hepatitis Virus Reduce Virus Replication: Preclinical Findings

SynopsisAll coronaviruses contain a small domain called the macrodomain, or Mac1, within the nonstructural protein 3 (nsp3). Mac1 binds to and removes a molecule called mono-ADP-ribose (MAR) that a...

The Effects of Nicotinamide Riboside on Color and Color Stability of Pork Chops: Preclinical Findings

SynopsisThis study tested whether nicotinamide riboside (NR) could improve the color and color stability of pork chops from pigs exposed to extreme stress before harvest. One hundred pigs received ...

The Effects of Boosting NAD+ on Atherosclerosis and Inflammation: Preclinical Findings

SynopsisNAD+ is a key molecule that activates sirtuins, which are linked to benefits like lifespan extension and improved metabolism in mice. Supplements like nicotinamide riboside (NR) are used to...

Targeting Autophagy-NAD Pathway Protects Cells in Niemann-Pick Type C1 Disease: Preclinical Findings

SynopsisImpaired autophagy, which leads to the buildup of misfolded proteins and damaged organelles, has been linked to many human diseases. Loss of autophagy in metabolically active cells can caus...

Synthesis and Stability of Dihydronicotinamide Riboside from Nicotinamide Riboside Chloride: Preclinical Findings

SynopsisNRH, a highly effective synthetic NAD+ precursor, was produced in high yield from nicotinamide riboside chloride (NRCl) using a water-based reduction process under low-oxygen conditions. Th...

Standardized Assay Quantifies NAD+ and NADH in Worms, Mice, and Human Blood: Preclinical Findings

SynopsisA standardized assay was developed to measure NAD+, NADH, and the NAD+/NADH ratio across multiple biological samples, including C. elegans, mouse muscle, mouse blood, and human blood. The p...

SARM1 Drives Nerve Damage Following Inflammation and Cell Death Signals: Preclinical Findings

SynopsisNeuroinflammation and a type of cell death called necroptosis play big roles in neurodegenerative diseases, often starting with damage to nerve fibers called axons. SARM1 is a key enzyme th...

Safety Evaluation of Nicotinamide Riboside: Preclinical Findings

SynopsisNicotinamide riboside (NR) is a natural form of vitamin B3 found in small amounts in foods. A synthetic version, Niagen™, was tested for safety using a series of lab and animal studies. The...

Role of nadR Gene in Growth and Virulence of Streptococcus suis Bacteria: Preclinical Findings

SynopsisStreptococcus suis serotype 2 (SS2) is a harmful bacterium in pigs that can also infect humans. This study investigated the role of the nadR gene, which helps make and transport NAD+ inside...

Restoring NAD+ with Nicotinamide Riboside Improves Metabolism and Autophagy in DNA Repair Deficiency: Preclinical Findings

SynopsisLoss of Rev1, a DNA repair protein, causes replication stress, mitochondrial dysfunction, and metabolic imbalance. This study found that mouse embryonic fibroblasts lacking Rev1 had altered...

Rare SARM1 Variants Linked to ALS and Motor Nerve Disorders: Preclinical Findings

SynopsisSARM1 is a protein that breaks down NAD+, playing a key role in axon degeneration. Researchers found seven rare SARM1 gene variants in patients with ALS or other motor nerve disorders. Thes...

Raising NAD+ via Nicotinamide Riboside Enhances Heart Function in Heart Failure: Preclinical Findings

SynopsisBoosting cellular NAD⁺ levels has been shown to prevent heart problems in various models of heart failure, but how it works at the molecular level is not fully understood. Most studies focu...

NMNAT1 Protects Injured Axons by Preventing SARM1-Induced NAD+ Loss After Injury: Preclinical Findings

SynopsisOverexpression of the NAD+ biosynthesis enzyme NMNAT1 helps protect injured axons. Although it's believed that higher NAD+ levels or lower NMN levels are important for this protection, the ...

NMN Converts to Nicotinamide Riboside Before Entering Cells: Preclinical Findings

SynopsisNAD+ is an essential molecule that helps enzymes like sirtuins and poly(ADP-ribose) polymerases work properly. Supplements like nicotinamide mononucleotide (NMN) and nicotinamide riboside (...

Nicotinamide Riboside-Supplemented Diet Delays Muscle Degeneration in Mice Lacking the NAMPT Gene: Preclinical Findings

SynopsisNAD+ helps enzymes keep energy balanced in cells, and the enzyme NAMPT controls how NAD+ is made. NAD+ is important for healthy muscle, but how it affects muscle growth isn't fully clear. T...

Nicotinamide Riboside Treatment Protects Retinal Cells in Mice: Preclinical Findings

SynopsisGlaucoma often involves death of retinal ganglion cells (RGCs), partly caused by high eye pressure (IOP). But even when IOP is controlled, the disease can still worsen. So, it's important t...

Nicotinamide Riboside Supports Pancreatic β-Cell Function During Aging and Diet Stress: Preclinical Findings

SynopsisDisturbances in NAD+ metabolism have been linked to many age-related and metabolic diseases like type 2 diabetes. Pancreatic β-cells play a key role in controlling blood sugar, but how NAD+...

Nicotinamide Riboside Supports Brain Health and Reduces Inflammation in Alzheimer’s Disease: Preclinical Findings

SynopsisNicotinamide riboside (NR), a precursor of NAD+, can improve cognitive function and reduce brain inflammation in Alzheimer's disease (AD) mouse models, even without affecting beta-amyloid p...