Nicotinamide Riboside Restores Lipid Handling in Diabetic Heart Disease: Preclinical Findings

Synopsis Excessive lipid droplet buildup and lipotoxicity contribute to diabetic cardiomyopathy (DCM). This study found that lipophagy—the autophagic breakdown of lipid droplets—is impaired in DCM...

NAD+ Restores Heart Function in Heart Failure via Ketone Production: Preclinical Findings

Synopsis Heart failure with preserved ejection fraction (HFpEF) is a common form of heart failure with few treatment options. This study found that the heart can make ketones using the enzyme HMGC...

Nicotinamide Riboside Reduces Inflammation in Retinal Degeneration: Preclinical Findings

Synopsis Bright light exposure triggers mitochondrial damage in the retina, releasing double-stranded DNA that activates the cGAS-STING inflammatory pathway and drives microglial pyroptosis, accel...

The Effects of Boosting NAD+ on Atherosclerosis and Inflammation: Preclinical Findings

SynopsisNAD+ is a key molecule that activates sirtuins, which are linked to benefits like lifespan extension and improved metabolism in mice. Supplements like nicotinamide riboside (NR) are used to...

Nicotinamide Riboside Improves Mitochondrial Health in Werner Syndrome: Preclinical Findings

SynopsisWerner syndrome (WS) is a rare accelerated aging disease caused by mutations in the WRN gene, leading to metabolic problems and premature cell aging. This study found that loss of WRN incre...

Nicotinamide Riboside Restores Mitochondrial Function in Alzheimer's Disease: Preclinical Findings

Synopsis Mutant APP and amyloid-β (Aβ) disrupt mitochondrial dynamics and damage synapses in Alzheimer’s disease (AD), partly due to impaired mitophagy, the removal of dysfunctional mitochondria. ...

Nicotinamide Riboside and NMN Boost NAD+ Through Microbiota Conversion: Preclinical Findings

Synopsis Using NAD+ metabolomics in mice, this study found that nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are not directly absorbed intact in large amounts. Instead, most or...

Nicotinamide Riboside and Necroptosis Inhibition Improve ALS: Preclinical Findings

Synopsis TBK1 loss-of-function mutations linked to amyotrophic lateral sclerosis (ALS) were modeled in zebrafish using CRISPR and morpholino knockdown. Both approaches caused early motor deficits,...

Nicotinamide Riboside Protects Against Chronic Kidney Disease by Boosting Metabolism: Preclinical Findings

SynopsisChronic kidney disease (CKD) impairs kidney metabolism, including fatty acid breakdown, and is linked to low NAD+ levels. This study tested nicotinamide riboside (NR), a precursor of NAD+, ...

Nicotinamide Riboside Protects Kidneys after Heart Attack: Preclinical Findings

SynopsisCardiorenal syndrome type 1 occurs when acute kidney injury (AKI) develops after sudden heart problems like a heart attack (MI), increasing the risk of death. This study tested whether nico...

NMN and NR Improve Lipid Metabolism but Promote Atherosclerosis in ApoE-Knockout Mice: Preclinical Findings

Synopsis Supplementation with nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) raised NAD+ levels and produced clear metabolic benefits in mice, including reduced body weight, lowe...

Roseburia hominis and Nicotinamide Riboside Combat Obesity: Preclinical Findings

Synopsis The gut bacterium Roseburia hominis was found to be depleted in obese individuals and negatively correlated with BMI and serum triglycerides. In high-fat diet–fed mice, supplementation wi...

The Effects of Nicotinamide Riboside on Color and Color Stability of Pork Chops: Preclinical Findings

SynopsisThis study tested whether nicotinamide riboside (NR) could improve the color and color stability of pork chops from pigs exposed to extreme stress before harvest. One hundred pigs received ...

Natural Nicotinamide Riboside–Loaded Stem Cell Extracellular Vesicles Synergistically Combat Aging: Preclinical Findings

Synopsis This study explored the potential of small extracellular vesicles (ASC-sEVs) from adipose-derived stem cells for skin care and anti-aging. Researchers purified ASC-sEVs and analyzed their...

Nicotinamide Riboside Counteracts Testicular Aging: Preclinical Findings

Synopsis Deleting Qprt, a key enzyme in the NAD+ de novo synthesis pathway and highly expressed in spermatocytes, did not disrupt NAD+ levels or spermatogenesis in young (3-month-old) mice. Howeve...

Mitochondrial Activators Like Nicotinamide Riboside Help Heart Cell Function: Preclinical Findings

SynopsisMitochondrial dysfunction in failing hearts can cause energy shortages in heart cells. This study tested how isoproterenol (ISO), a compound that stresses heart cells, affects mitochondria ...

CD38 Converts NMN to NaMN Through Base Exchange: Preclinical Findings

Synopsis Nicotinamide mononucleotide (NMN) is generally assumed to boost NAD+ by feeding directly into the canonical salvage pathway. However, this study shows that NMN treatment unexpectedly incr...

Nicotinamide Riboside Protects Liver Cells from Palmitate-Induced Damage: Preclinical Findings

Synopsis This study examined how excessive fat buildup in liver cells (hepatic lipotoxicity) contributes to liver damage, a key factor in metabolic liver diseases. Researchers found that exposure ...

Nicotinamide Riboside Mitigates Diabetes-Related Bone Loss: Preclinical Findings

Synopsis Type 2 diabetes mellitus (T2DM) caused by high-fat diet/streptozotocin treatment led to impaired bone microarchitecture and bone loss in mice, along with metabolic dysfunction. Supplement...

Nicotinamide Riboside Reduces Sweetener-Induced Neurocognitive Impairments: Preclinical Findings

Synopsis Around the world, many people consume sweeteners, with sweet beverages being a major source. Previous studies have shown that too many sweeteners can harm health, including affecting brai...