Nicotinamide Riboside Improves Ovarian Function in PCOS: Preclinical Findings

Synopsis In a DHEA-induced mouse model of polycystic ovary syndrome (PCOS), ovarian NAD+ levels dropped sharply, leading to mitochondrial dysfunction in granulosa cells, stromal cells, and oocytes...

NR and Inosine Restore Metabolic Activity in NAXD-Deficient Cells: Preclinical Findings

Synopsis Mutations in the metabolite-repair enzyme NAXD, which normally converts damaged NADHX/NADPHX back into functional cofactors, cause the severe neurometabolic disorder PEBEL2. In human NAXD...

Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

SynopsisAlzheimer's disease (AD) impairs brain energy metabolism and mitochondrial function, with potential differences between males and females. This study tested whether a ketogenic diet and/or ...

Nicotinamide Riboside Helps Maintain Mitochondrial Health and Meat Quality in Pork: Preclinical Findings

SynopsisEarly postmortem muscle mitochondrial function and cell death affect pork quality, including color stability. This study tested whether nicotinamide riboside (NR) given to pigs before harve...

Nicotinamide Riboside Blocks LPS-Induced Microglial Inflammation: Preclinical Findings

Synopsis In LPS-stimulated BV2 microglia, nicotinamide riboside (NR) restored mitochondrial function and reduced inflammation by activating the AMPK–SIRT3 signaling axis. NR shifted microglia from...

Nicotinamide Riboside Protects Bones via Mitochondrial Support: Preclinical Findings

Synopsis This study uncovered how gut microbiota imbalances contribute to osteoporosis through the overproduction of trimethylamine-N-oxide (TMAO), a metabolite formed from L-carnitine by intestin...

Nicotinamide Riboside Protects Liver Immune Cells from Alcohol-Induced Damage: Preclinical Findings

SynopsisAlcohol-related liver disease (ALD) is linked to mitochondrial dysfunction and impaired energy metabolism. This study examined how ethanol damages Kupffer cells, the liver's resident immune...

Urolithin A and Nicotinamide Riboside Support Brain Immune Cells and Mitochondrial Health: Preclinical Findings

SynopsisDuring aging, many cellular processes, including DNA repair, energy production, and immune function, become less efficient. This study examined how two natural compounds, Urolithin A (UA) a...

Nicotinamide Riboside and Resveratrol Enhance Wound Healing in Diabetic Rats: Preclinical Findings

Synopsis Diabetes impairs wound healing by disrupting autophagy and promoting apoptosis. In a type 1 diabetic rat model, systemic and topical nicotinamide riboside (NR) and resveratrol (RSV) signi...

Nicotinamide Riboside Improves Fructose-Induced Lipid Metabolism Disorders: Preclinical Findings

Synopsis This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ booster, protects against fat metabolism disorders caused by high fructose intake. Mice given a 20% fructose ...

Effects of Nicotinamide, Pyridoxine, Nicotinamide Riboside, and Nicotinamide Mononucleotide on Muscle Stem Cells and Regeneration: Preclinical Findings

SynopsisSkeletal muscle depends on muscle stem cells (MuSCs) for growth and repair, but aging and muscle diseases reduce their function, leading to muscle loss and weakness. This study tested nicot...

NR Restores Mitochondrial Function and Reduces Trigeminal Pain: Preclinical Findings

Synopsis In a mouse model of trigeminal neuropathic pain, the injured trigeminal ganglion (TG) showed profound mitochondrial dysfunction, affecting gene expression, protein synthesis, and respirat...

Nicotinamide Riboside Protects Dopamine Neurons in Parkinson's Disease: Preclinical Findings

Synopsis This study identified the essential role of NAMPT, an enzyme that helps produce NAD+, in protecting dopaminergic neurons—the brain cells that control movement and are lost in Parkinson’s ...

Standardized Assay Quantifies NAD+ and NADH in Worms, Mice, and Human Blood: Preclinical Findings

SynopsisA standardized assay was developed to measure NAD+, NADH, and the NAD+/NADH ratio across multiple biological samples, including C. elegans, mouse muscle, mouse blood, and human blood. The p...

Nicotinamide Riboside Protects Brain Development from Drug Toxicity: Preclinical Findings

Synopsis This study explored the potential neurodevelopmental risks of oseltamivir phosphate (OSE)—a widely used antiviral drug also found in the environment—using zebrafish models. Researchers di...

Nicotinamide Riboside Inhibits CD38 in Living Cells: Preclinical Findings

Synopsis Nicotinamide adenine dinucleotide (NAD+) is essential for energy production, metabolism, and cell signaling, but its levels naturally decline with age and disease. One key reason for this...

Nicotinamide Riboside Preserves Oocyte Quality and Prevents Postovulatory Aging: Preclinical Findings

Synopsis After ovulation, oocytes (eggs) begin to age, leading to lower fertilization success and embryo quality during assisted reproductive technologies (ART) such as IVF. This process, known as...

Nicotinamide Riboside Protects CD8+ T Cells From Exhaustion by Improving Mitochondrial Health: Preclinical Findings

SynopsisProtecting mitochondria in CD8+ T cells is important for improving cancer immunotherapy. This study tested whether nicotinamide riboside (NR) could prevent T cell exhaustion. In lab models,...

Nicotinamide Riboside Protects Retinal Ganglion Cells: Preclinical Findings

Synopsis Glaucoma causes vision loss by damaging retinal ganglion cells (RGCs)—the neurons that carry visual information to the brain. One key cause of this damage is glutamate excitotoxicity, whe...

NAD+ Depletion Is Central to Placental Dysfunction in an Inflammatory Subclass of Preeclampsia: Preclinical Findings

Synopsis Preeclampsia (PE) is a dangerous pregnancy complication marked by high blood pressure, inflammation, and placental dysfunction, leading to serious risks for both mother and baby. This stu...