Article: Nicotinamide Riboside Improves Ovarian Function in PCOS: Preclinical Findings

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Polycystic Ovary Syndrome (PCOS) Preclinical Reproductive Health

Nicotinamide Riboside Improves Ovarian Function in PCOS: Preclinical Findings

Synopsis

In a DHEA-induced mouse model of polycystic ovary syndrome (PCOS), ovarian NAD+ levels dropped sharply, leading to mitochondrial dysfunction in granulosa cells, stromal cells, and oocytes. This caused irregular estrous cycles, reduced ovulation potential, increased ovarian fibrosis, and poor oocyte quality marked by excess ROS, abnormal mitochondrial clustering, low membrane potential, spindle defects, and impaired early embryonic development. Supplementation with nicotinamide riboside (NR) prevented ovarian NAD+ decline, normalized reproductive cycles, reduced fibrosis, restored mitochondrial function, and enhanced both the quantity and quality of oocytes. Fertilized oocytes from NR-treated PCOS mice showed significantly improved early embryonic development. These findings indicate that boosting ovarian NAD+ through NR is a promising therapeutic strategy for treating PCOS-related infertility.

Journal

Journal of Ovarian Research

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Alzheimer's Disease

Nicotinamide Riboside Supplementation Improves Alzheimer's Biomarkers in Subjective Cognitive Decline and Mild Cognitive Impairment: Clinical Findings

Objectives To test the safety and efficacy of oral NR supplementation on cognition and Alzheimer's disease (AD) blood biomarkers in older adults with subjective cognitive decline and mild cognitiv...

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Neurological Health

Nicotinamide Riboside Reduces Sweetener-Induced Neurocognitive Impairments: Preclinical Findings

Synopsis Around the world, many people consume sweeteners, with sweet beverages being a major source. Previous studies have shown that too many sweeteners can harm health, including affecting brai...

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