Article: Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

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Alzheimer's Disease Mitochondrial Health Neurological Health Preclinical

Ketogenic Diet and Nicotinamide Riboside Improve Brain Energy Metabolism in Alzheimer's Disease: Preclinical Findings

Synopsis

Alzheimer's disease (AD) impairs brain energy metabolism and mitochondrial function, with potential differences between males and females. This study tested whether a ketogenic diet and/or nicotinamide riboside (NR) could restore energy in the hippocampus of older mice, including DNA repair–deficient AD models. In male mice, both NR and a ketogenic diet improved mitochondrial energy and key metabolic intermediates. In female mice, only the ketogenic diet effectively restored mitochondrial energy. These findings suggest that NR and ketones can support hippocampal energy in AD, but the benefits depend on sex and disease context.

Journal

Journal of Neurochemistry

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Neurological Health

Low NMNAT2 Triggers SARM1 Activity and Alters Nicotinamide Riboside Response in Axons: Preclinical Findings

SynopsisNMNAT2 is a key protein that keeps axons healthy by blocking the pro-degenerative protein SARM1. Completely losing NMNAT2 in mice causes severe axon loss and early death, but removing SARM1...

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Increasing NAD+ Production in Muscle Alone Does Not Improve Metabolism: Preclinical Findings

SynopsisNicotinamide mononucleotide (NMN) and nicotinamide riboside (NR), precursors of NAD+, are known to help resist metabolic problems caused by high-fat diets partly by boosting oxidative metab...

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