Nicotinamide Riboside Restores NAD+ in RYR1-Related Muscle Diseases: Preclinical Findings

Synopsis Mutations in the RYR1 gene cause a group of rare congenital muscle diseases (RYR1-RM) characterized by problems in calcium regulation within muscle cells, leading to muscle weakness and f...

Stem Cell Membrane–Coated Nanodrugs with Nicotinamide Riboside Targets Alzheimer's Disease: Preclinical Findings

Synopsis Alzheimer’s disease (AD) is a complex neurodegenerative disorder that urgently requires more effective, precisely targeted treatments. This study developed a biomimetic nanomedicine desig...

Reishi Mushroom Delays Kidney Aging Through Gut Microbiota and Nicotinamide Riboside: Preclinical Findings

Synopsis Ganoderma lucidum (G. lucidum), also known as Reishi mushroom, has been valued in traditional Chinese medicine (TCM) for its anti-aging and kidney-protective properties. This study explor...

Nicotinamide Riboside Increases Stress Sensitivity and Alters Blood Cell Composition in Aging: Preclinical Findings

SynopsisNicotinamide riboside (NR) is a precursor to NAD⁺, a key molecule for cellular energy that declines with age. Aging can cause reduced brain and immune function, changes in blood, and greate...

Nicotinamide Riboside Restores Vascular Health in ACTA2 Mutation: Preclinical Findings

Synopsis Mutations in ACTA2 affecting arginine 179 cause early-onset strokes due to moyamoya-like artery blockages. This study found that mutant smooth muscle cells (SMCs) remain immature, highly ...

Nicotinamide Riboside Enhances Milk Production in Lactating Sows: Preclinical Findings

Synopsis Lactation insufficiency is a common challenge with unclear biological causes. This study examined how nicotinamide riboside (NR), a vitamin B3–derived NAD+ precursor, influences mammary g...

Nicotinamide Riboside Protects Against Heat Stress–Induced Testicular Damage and Improves Boar Fertility: Preclinical Findings

Synopsis Heat stress (HS) from rising global temperatures negatively affects male fertility, damaging the testes and reducing semen quality. This study examined how HS alters testicular NAD+ metab...

Nicotinamide Riboside Enhances NK Cell Anti-Tumor Activity: Preclinical Findings

Synopsis Tumor-produced lactate weakens natural killer (NK) cells by causing lysine lactylation (Kla), disrupting NAD+ metabolism, and fragmenting mitochondria, which reduces cytotoxicity. Supplem...

Nicotinamide Riboside Restores Mitochondrial Function in Aortic Aneurysms: Preclinical Findings

Synopsis Thoracic aortic aneurysms (TAA) are deadly vascular disorders linked to genetic mutations such as ACTA2R179H and TGFBR2G357W, which disrupt vascular smooth muscle cell (VSMC) function. Th...

Nicotinamide Riboside and NMN Enhance CAR-T Cell Function in Aging: Preclinical Findings

Synopsis Chimeric antigen receptor (CAR) T cell therapy is a powerful cancer treatment, but its effectiveness declines with aging. This study found that CAR-T cells from aged female mice show mito...

NAD+ Deficiency Drives Kidney Dysfunction in Cockayne Syndrome: Preclinical Findings

SynopsisCockayne Syndrome (CS) is a premature aging disorder caused by mutations in the CSA and CSB genes, leading to problems like early aging, nerve damage, and kidney dysfunction. Cells from CS ...

Nicotinamide Riboside Reduces Kidney Damage in Chronic Disease: Preclinical Findings

Synopsis Subclinical chronic kidney disease (sCKD) increases vulnerability to acute kidney injury (AKI). In a rat model where ischemia–reperfusion injury (IRI) was applied on top of sCKD, a dual t...

Nicotinamide Riboside Protects the Intestinal Barrier From Heat Stress: Preclinical Findings

Synopsis Heat stress damages the intestinal epithelial barrier, allowing harmful substances to enter the body. This study tested whether nicotinamide riboside (NR), a NAD+ precursor, could protect...

Nicotinamide Riboside Restores Mitochondrial Activity and Thermogenesis in Brown Fat: Preclinical Findings

Synopsis Brown adipose tissue (BAT) depends on NAD+ biosynthesis for healthy mitochondrial function and thermogenesis. Multi-omics analysis of BXD mouse strains showed that BAT NAD+ metabolism str...

Safety of Intravenous Nicotinamide Riboside Across Multiple Doses in Rats: Preclinical Findings

Synopsis This study evaluated the safety of repeated intravenous nicotinamide riboside (NR) at varying doses in Wistar rats. NR was well-tolerated at 150, 300, and 450 mg/kg, with no adverse effec...

Nicotinamide Riboside Protects Against Doxorubicin Cardiotoxicity: Preclinical Findings

Synopsis In human iPSC-derived cardiomyocytes, nicotinamide riboside (NR) improved mitochondrial fusion, enhanced oxidative phosphorylation and ATP production, and upregulated ERRα, a key metaboli...

Nicotinamide Riboside Prevents Oocyte Quality Loss in Maternal Diabetes: Preclinical Findings

Synopsis Diabetes reduces NAD+ levels in ovaries and oocytes, leading to poor oocyte quality, abnormal spindle formation, excess ROS, and impaired embryo development. In streptozotocin-induced dia...

Mixed-Mode LC-MS Method Quantifies NAD+ and Its Metabolites: Preclinical Findings

Synopsis Measuring NAD+ and its metabolites is technically difficult because these molecules are highly polar and poorly retained by standard chromatography. This study developed a robust mixed-mo...

Combined Metabolic Activators Improve Brain and Liver Function in Alzheimer's and Parkinson's Disease: Preclinical Findings

Synopsis Mitochondrial dysfunction and metabolic problems are major contributors to neurodegenerative diseases such as Parkinson’s (PD) and Alzheimer’s (AD). Research shows that combined metabolic...

Nicotinamide Riboside Alleviates Bone Cancer Pain by Restoring Mitochondrial Function: Preclinical Findings

Synopsis Bone cancer pain (BCP) disrupts mitochondrial function in spinal cord neurons, leading to damaged mitochondrial structure, reduced ATP production, and decreased membrane potential (MMP). ...